Effects of intracoronary stem cell transplantation in patients with dilated cardiomyopathy

Bojan Vrtovec, Gregor Poglajen, Matjaz Sever, Luka Lezaic, Dragoslav Domanovic, Peter Cernelc, Franois Haddad, Guillermo Torre-Amione

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

Background: We investigated clinical effects of intracoronary transplantation of CD34+ cells in patients with dilated cardiomyopathy (DCM). Methods: Of 55 patients with DCM, 28 were randomized to CD34+ transplantation (SC group), and 27 patients did not receive stem cell therapy (controls). In the SC group, peripheral blood CD34+ cells were mobilized by granulocyte-colony stimulating factor and collected via apheresis. Patients underwent myocardial scintigraphy and CD34+ cells were injected in the coronary artery supplying the segments with reduced viability. Results: At baseline, the 2 groups did not differ in age, gender, left ventricular ejection fraction (LVEF), or NT-proBNP levels. At 1 year, stem cell therapy was associated with an increase in LVEF (from 25.5 ± 7.5% to 30.1 ± 6.7%; P = .03), an increase in 6-minute walk distance (from 359 ± 104 m to 485 ± 127 m; P = .001), and a decrease in NT-proBNP (from 2069 ± 1996 pg/mL to 1037 ± 950 pg/mL; P = .01). The secondary endpoint of 1-year mortality or heart transplantation was lower in patients receiving SC therapy (2/28, 7%) than in controls (8/27, 30%) (P = .03), and SC therapy was the only independent predictor of outcome on multivariable analysis (P = .04). Conclusions: Intracoronary stem cell transplantation could lead to improved ventricular remodeling, better exercise tolerance and potentially improved survival in patients with DCM.

Original languageEnglish (US)
Pages (from-to)272-281
Number of pages10
JournalJournal of Cardiac Failure
Volume17
Issue number4
DOIs
StatePublished - Apr 2011

Keywords

  • Cardiomyopathy
  • heart Failure
  • stem Cells

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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