TY - JOUR
T1 - Effects of hydrogen bonding on amide-proton chemical shift anisotropy in a proline-containing model peptide
AU - Pichumani, Kumar
AU - George, Gijo
AU - Hebbar, Sankeerth
AU - Chatterjee, Bhaswati
AU - Raghothama, Srinivasarao
N1 - Funding Information:
We are grateful to Prof. Anil Kumar of Physics Department and Prof. P. Balaram of Molecular Biophysics Unit of Indian Institute of Science, Bangalore, India for their support and encouragement of this work. We thank Prof. K.V. Ramanathan for his suggestions and critical reading of the manuscript. Financial support from Department of Science and Technology of Government of India (to S.R.) is also acknowledged.
Publisher Copyright:
© 2015 Elsevier B.V. All rights reserved.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Abstract Longitudinal relaxation due to cross-correlation between dipolar (1HN-1Hα) and amide-proton chemical shift anisotropy (1HN CSA) has been measured in a model tripeptide Piv-LPro-LPro-LPhe-OMe. The peptide bond across diproline segment is known to undergo cis/trans isomerization and only in the cis form does the lone Phe amide-proton become involved in intramolecular hydrogen bonding. The strength of the cross correlated relaxation interference is found to be significantly different between cis and trans forms, and this difference is shown as an influence of intramolecular hydrogen bonding on the amide-proton CSA.
AB - Abstract Longitudinal relaxation due to cross-correlation between dipolar (1HN-1Hα) and amide-proton chemical shift anisotropy (1HN CSA) has been measured in a model tripeptide Piv-LPro-LPro-LPhe-OMe. The peptide bond across diproline segment is known to undergo cis/trans isomerization and only in the cis form does the lone Phe amide-proton become involved in intramolecular hydrogen bonding. The strength of the cross correlated relaxation interference is found to be significantly different between cis and trans forms, and this difference is shown as an influence of intramolecular hydrogen bonding on the amide-proton CSA.
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U2 - 10.1016/j.cplett.2015.03.048
DO - 10.1016/j.cplett.2015.03.048
M3 - Article
AN - SCOPUS:84927617938
SN - 0009-2614
VL - 627
SP - 126
EP - 129
JO - Chemical Physics Letters
JF - Chemical Physics Letters
M1 - 32894
ER -