Effects of Hexachlorophene, a Chemical Accumulating in Adipose Tissue, on Mouse and Human Mesenchymal Stem Cells

Monika Leśniak; Robert Zdanowski; Milena Suska; Aleksandra Brewczyńska; Wanda Stankiewicz; Małgorzata Kloc; Jacek Z. Kubiak; Sławomir Lewicki

doi:10.1007/s13770-017-0103-9

Effects of Hexachlorophene, a Chemical Accumulating in Adipose Tissue, on Mouse and Human Mesenchymal Stem Cells

Monika Leśniak, Robert Zdanowski, Milena Suska, Aleksandra Brewczyńska, Wanda Stankiewicz, Małgorzata Kloc, Jacek Z. Kubiak, Sławomir Lewicki

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The hexachlorophene (HCP) is a highly lipophilic chlorinated bisphenol present in hygienic and dermatological products. The HCP accumulates preferentially in adipose tissue that is a privileged source of mesenchymal stem cells (MSCs). The evaluation of the potential effects of HCP on MSCs is important for their medical application. Here we examined the effects of HCP on murine adipose tissue-derived stem cells (ADSCs) and human umbilical cord-derived stem cells (UCSCs) in cell culture. We found that 10⁻⁴and 10⁻⁵ M HCP inhibits proliferation, osteogenesis and increases apoptosis of ADSCs and UCSCs. While the effect of HCP on proliferation and differentiation potential of these two cell lines was similar, the UCSCs appeared much more resistant to HCP-induced apoptosis than ADSCs. These results suggest that the adipose tissue-derived ADSCs have higher sensitive for HCP than umbilical cord-derived UCSCs and indicate that the umbilical cord can be a preferable source of MSCs for prospective medical applications in the future.

Original language	English (US)
Pages (from-to)	211-222
Number of pages	12
Journal	Tissue Engineering and Regenerative Medicine
Volume	15
Issue number	2
DOIs	https://doi.org/10.1007/s13770-017-0103-9
State	Published - Apr 1 2018

Keywords

Adipose tissue
Apoptosis
Hexachlorophene
Mesenchymal stem cells
Unbilical cord

ASJC Scopus subject areas

Medicine (miscellaneous)
Biomedical Engineering

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title = "Effects of Hexachlorophene, a Chemical Accumulating in Adipose Tissue, on Mouse and Human Mesenchymal Stem Cells",

abstract = "The hexachlorophene (HCP) is a highly lipophilic chlorinated bisphenol present in hygienic and dermatological products. The HCP accumulates preferentially in adipose tissue that is a privileged source of mesenchymal stem cells (MSCs). The evaluation of the potential effects of HCP on MSCs is important for their medical application. Here we examined the effects of HCP on murine adipose tissue-derived stem cells (ADSCs) and human umbilical cord-derived stem cells (UCSCs) in cell culture. We found that 10−4and 10−5 M HCP inhibits proliferation, osteogenesis and increases apoptosis of ADSCs and UCSCs. While the effect of HCP on proliferation and differentiation potential of these two cell lines was similar, the UCSCs appeared much more resistant to HCP-induced apoptosis than ADSCs. These results suggest that the adipose tissue-derived ADSCs have higher sensitive for HCP than umbilical cord-derived UCSCs and indicate that the umbilical cord can be a preferable source of MSCs for prospective medical applications in the future.",

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AU - Leśniak, Monika

AU - Zdanowski, Robert

AU - Suska, Milena

AU - Brewczyńska, Aleksandra

AU - Stankiewicz, Wanda

AU - Kloc, Małgorzata

AU - Kubiak, Jacek Z.

AU - Lewicki, Sławomir

PY - 2018/4/1

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N2 - The hexachlorophene (HCP) is a highly lipophilic chlorinated bisphenol present in hygienic and dermatological products. The HCP accumulates preferentially in adipose tissue that is a privileged source of mesenchymal stem cells (MSCs). The evaluation of the potential effects of HCP on MSCs is important for their medical application. Here we examined the effects of HCP on murine adipose tissue-derived stem cells (ADSCs) and human umbilical cord-derived stem cells (UCSCs) in cell culture. We found that 10−4and 10−5 M HCP inhibits proliferation, osteogenesis and increases apoptosis of ADSCs and UCSCs. While the effect of HCP on proliferation and differentiation potential of these two cell lines was similar, the UCSCs appeared much more resistant to HCP-induced apoptosis than ADSCs. These results suggest that the adipose tissue-derived ADSCs have higher sensitive for HCP than umbilical cord-derived UCSCs and indicate that the umbilical cord can be a preferable source of MSCs for prospective medical applications in the future.

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Effects of Hexachlorophene, a Chemical Accumulating in Adipose Tissue, on Mouse and Human Mesenchymal Stem Cells

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