Effects of gestational age and surface modification on materno-fetal transfer of nanoparticles in murine pregnancy

Hui Yang, Cuiji Sun, Zhenlin Fan, Xin Tian, Liang Yan, Libo Du, Yang Liu, Chunying Chen, Xing Jie Liang, Gregory J. Anderson, Jeffrey A. Keelan, Yuliang Zhao, Guangjun Nie

Research output: Contribution to journalArticle

89 Scopus citations

Abstract

Nanoparticle exposure in pregnancy may result in placental damage and fetotoxicity; however, the factors that determine fetal nanoparticle exposure are unclear. Here we have assessed the effect of gestational age and nanoparticle composition on fetal accumulation of maternally-administered nanomaterials in mice. We determined the placental and fetal uptake of 13...nm gold nanoparticles with different surface modifications (ferritin, PEG and citrate) following intravenous administration at E5.5-15.5. We showed that prior to E11.5, all tested nanoparticles could be visualized and detected in fetal tissues in significant amounts; however, fetal gold levels declined dramatically post-E11.5. In contrast, Au-nanoparticle accumulation in the extraembryonic tissues (EET) increased 6-15 fold with gestational age. Fetal and EET accumulation of ferritin-and PEG-modified nanoparticles was considerably greater than citrate-capped nanoparticles. No signs of toxicity were observed. Fetal exposure to nanoparticles in murine pregnancy is, therefore, influenced by both stage of embryonic/placental maturation and nanoparticle surface composition.

Original languageEnglish (US)
Article number847
JournalScientific Reports
Volume2
DOIs
StatePublished - 2012

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Effects of gestational age and surface modification on materno-fetal transfer of nanoparticles in murine pregnancy'. Together they form a unique fingerprint.

Cite this