TY - JOUR
T1 - Effects of exercise training on left ventricular performance and myocardial perfusion in patients with coronary artery disease
AU - Verani, Mario S.
AU - Harley Hartung, G.
AU - Hoepfel-Harris, Jean
AU - Welton, David E.
AU - Pratt, Craig
AU - Miller, Richard R.
PY - 1981/1/1
Y1 - 1981/1/1
N2 - To determine the effects of exercise training on left ventricular performance and myocardial perfusion in coronary artery disease, rest and exercise radionuclide angiocardiography and thallium-201 scintigraphy were performed before and after 12 weeks of training in 16 coronary patients. After training, 15 of the 16 patients had improved exercise tolerance; total treadmill exercise duration increased from (mean ± standard error of the mean) 491 ± 37 to 602 ± 31 seconds (p < 0.01), and the estimated rate of oxygen consumption (VO2 max) increased from 29.4 ± 1.4 to 33.8 ± 1.2 ml/kg per min (p < 0.001). Resting left ventricular ejection fraction increased from 52 ± 4 to 57 ± 4 percent (p < 0.02); no change occurred in left ventricular functional reserve assessed by ejection fraction and regional wall motion response to exercise at the same ratepressure product before and after training. Myocardial perfusion at equivalent pre- and post-training cardiac work loads during exercise and on redistribution was unchanged by training. It is concluded that in patients with coronary heart disease, physical training increases exercise tolerance, and results in minimal improvement in resting left ventricular systolic performance. Functional reserve of both left ventricular systolic performance and the coronary circulation appears to be unchanged by exercise training. These data suggest that the beneficial effects of training for 12 weeks in patients with coronary artery disease predominantly result from factors other than improvement in left ventricular pump performance or perfusion.
AB - To determine the effects of exercise training on left ventricular performance and myocardial perfusion in coronary artery disease, rest and exercise radionuclide angiocardiography and thallium-201 scintigraphy were performed before and after 12 weeks of training in 16 coronary patients. After training, 15 of the 16 patients had improved exercise tolerance; total treadmill exercise duration increased from (mean ± standard error of the mean) 491 ± 37 to 602 ± 31 seconds (p < 0.01), and the estimated rate of oxygen consumption (VO2 max) increased from 29.4 ± 1.4 to 33.8 ± 1.2 ml/kg per min (p < 0.001). Resting left ventricular ejection fraction increased from 52 ± 4 to 57 ± 4 percent (p < 0.02); no change occurred in left ventricular functional reserve assessed by ejection fraction and regional wall motion response to exercise at the same ratepressure product before and after training. Myocardial perfusion at equivalent pre- and post-training cardiac work loads during exercise and on redistribution was unchanged by training. It is concluded that in patients with coronary heart disease, physical training increases exercise tolerance, and results in minimal improvement in resting left ventricular systolic performance. Functional reserve of both left ventricular systolic performance and the coronary circulation appears to be unchanged by exercise training. These data suggest that the beneficial effects of training for 12 weeks in patients with coronary artery disease predominantly result from factors other than improvement in left ventricular pump performance or perfusion.
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U2 - 10.1016/0002-9149(81)90176-4
DO - 10.1016/0002-9149(81)90176-4
M3 - Article
C2 - 7211694
AN - SCOPUS:0019508310
VL - 47
SP - 797
EP - 803
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 4
ER -