Effects of dioxane on RNA synthesis in the rat liver

Rabinder N. Kurl, Lorenz Poellinger, Johan Lund, Jan-Ake Gustafsson

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The effect of dioxane on transcription was investigated. On intravenous administration of the lower dose (10 mg/rat) both RNA polymerase A and B activities were initially depressed but recovered after 1 h. A secondary effect on RNA polymerase A was observed but the enzyme activity recovered at 24 h when it was about 35% above control values whereas RNA polymerase B activity had achieved control values. With a higher dose (100 mg/rat) the pattern was similar but the suppressive effects were more pronounced - RNA polymerase B activity never attained control values during the times studied whereas there was no increase in RNA polymerase A activity at 24 h.

Original languageEnglish (US)
Pages (from-to)29-33
Number of pages5
JournalArchives of Toxicology
Volume49
Issue number1
DOIs
StatePublished - Nov 1 1981

Keywords

  • Carcinogen
  • Dioxane
  • Liver
  • RNA polymerases
  • Transcription

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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