Effects of bromocriptine on 3H-spiroperidol binding sites in rat striatum. Evidence for actions of dopamine receptors not linked to adenylate cyclase

Robert Schwarcz; Kjell Fuxe; Luigi F. Agnati; Jan-Ake Gustafsson

doi:10.1016/0024-3205(78)90154-6

Effects of bromocriptine on ³H-spiroperidol binding sites in rat striatum. Evidence for actions of dopamine receptors not linked to adenylate cyclase

Robert Schwarcz, Kjell Fuxe, Luigi F. Agnati, Jan-Ake Gustafsson

Research output: Contribution to journal › Article › peer-review

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Abstract

The present findings indicate, in agreement with previous work, that there may exist at least two types of dopamine (DA) receptors within the neostriatum, one linked to the adenylate cyclase system and one present on axon terminals belonging to corticostriatal fibres. Spiroperidol may have a somewhat higher affinity for the axonic DA receptors than for the DA receptors linked to the adenylate cyclase system. Finally, Bromocriptine has a high affinity for both axonic DA receptors and some DA receptors associated with adenylate cyclase which are localized on neostriatal interneurons.

Original language	English (US)
Pages (from-to)	465-469
Number of pages	5
Journal	Life sciences
Volume	23
Issue number	5
DOIs	https://doi.org/10.1016/0024-3205(78)90154-6
State	Published - Aug 7 1978

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(78)90154-6

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abstract = "The present findings indicate, in agreement with previous work, that there may exist at least two types of dopamine (DA) receptors within the neostriatum, one linked to the adenylate cyclase system and one present on axon terminals belonging to corticostriatal fibres. Spiroperidol may have a somewhat higher affinity for the axonic DA receptors than for the DA receptors linked to the adenylate cyclase system. Finally, Bromocriptine has a high affinity for both axonic DA receptors and some DA receptors associated with adenylate cyclase which are localized on neostriatal interneurons.",

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AU - Schwarcz, Robert

AU - Fuxe, Kjell

AU - Agnati, Luigi F.

AU - Gustafsson, Jan-Ake

PY - 1978/8/7

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N2 - The present findings indicate, in agreement with previous work, that there may exist at least two types of dopamine (DA) receptors within the neostriatum, one linked to the adenylate cyclase system and one present on axon terminals belonging to corticostriatal fibres. Spiroperidol may have a somewhat higher affinity for the axonic DA receptors than for the DA receptors linked to the adenylate cyclase system. Finally, Bromocriptine has a high affinity for both axonic DA receptors and some DA receptors associated with adenylate cyclase which are localized on neostriatal interneurons.

AB - The present findings indicate, in agreement with previous work, that there may exist at least two types of dopamine (DA) receptors within the neostriatum, one linked to the adenylate cyclase system and one present on axon terminals belonging to corticostriatal fibres. Spiroperidol may have a somewhat higher affinity for the axonic DA receptors than for the DA receptors linked to the adenylate cyclase system. Finally, Bromocriptine has a high affinity for both axonic DA receptors and some DA receptors associated with adenylate cyclase which are localized on neostriatal interneurons.

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Effects of bromocriptine on ³H-spiroperidol binding sites in rat striatum. Evidence for actions of dopamine receptors not linked to adenylate cyclase

Abstract

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