Effects of bromocriptine on 3H-spiroperidol binding sites in rat striatum. Evidence for actions of dopamine receptors not linked to adenylate cyclase

Robert Schwarcz, Kjell Fuxe, Luigi F. Agnati, Jan-Ake Gustafsson

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

The present findings indicate, in agreement with previous work, that there may exist at least two types of dopamine (DA) receptors within the neostriatum, one linked to the adenylate cyclase system and one present on axon terminals belonging to corticostriatal fibres. Spiroperidol may have a somewhat higher affinity for the axonic DA receptors than for the DA receptors linked to the adenylate cyclase system. Finally, Bromocriptine has a high affinity for both axonic DA receptors and some DA receptors associated with adenylate cyclase which are localized on neostriatal interneurons.

Original languageEnglish (US)
Pages (from-to)465-469
Number of pages5
JournalLife sciences
Volume23
Issue number5
DOIs
StatePublished - Aug 7 1978

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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