Effects of angiotensin receptor blocker on oxidative stress and cardio-renal function in streptozotocin-induced diabetic rats

Wawaimuli Arozal, Kenichi Watanabe, Punniyakoti Thanikachalam Veeraveedu, Meilei Ma, Rajarajan Amirthalingam Thandavarayan, Kenji Suzuki, Hitoshi Tachikawa, Makoto Kodama, Yoshifusa Aizawa

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

The important role of renin-angiotensin-aldosterone system blockade in the treatment of diabetes-induced cardiomyopathy and nephropathy has been clearly established. The present study examined the effect of angiotensin II type 1 receptor blocker (ARB) losartan on oxidative stress and cardio-renal function in streptozotocin (STZ)-induced diabetic rats. Losartan treatment resulted in improvement of myocardial function and suppressed cardiac and renal fibrosis compared with the diabetic group. Losartan treatment also down-regulated transforming growth factor-β1 expression and attenuated the increased expression levels of p22phox and Nox4. Blood urea nitrogen (BUN) and urinary protein levels were increased significantly in the diabetic group. Losartan treatment significantly reduced proteinuria but not BUN level. Moreover, the elevated level of malondialdehyde in both heart and kidney were significantly reduced in the losartan-treated group compared with the diabetic group. These results provided evidence that oxidative stress plays a major role in diabetic rats induced by STZ, and treatment with the ARB might be beneficial for preventing the development and progression of diabetic disease.

Original languageEnglish (US)
Pages (from-to)1411-1416
Number of pages6
JournalBiological and Pharmaceutical Bulletin
Volume32
Issue number8
DOIs
StatePublished - Aug 2009

Keywords

  • Angiotensin receptor blocker
  • Diabetes mellitus
  • Heart
  • Kidney
  • Oxidative stress

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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