Effects of adipose-derived biogenic nanoparticle-associated microrna-451a on toll-like receptor 4-induced cytokines

Xinghua Wang, Anthony Pham, Lu Kang, Sierra A. Walker, Irina Davidovich, Dalila Iannotta, Sarvam P. Terkonda, Shane Shapiro, Yeshayahu Talmon, Si Pham, Joy Wolfram

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Extracellular vesicles (EVs) are cell-released nanoparticles that transfer biomolecular content between cells. Among EV-associated biomolecules, microRNAs (miRNAs/miRs) represent one of the most important modulators of signaling pathways in recipient cells. Previous studies have shown that EVs from adipose-derived mesenchymal stromal cells (MSCs) and adipose tissue modulate inflammatory pathways in macrophages. In this study, the effects of miRNAs that are abundant in adipose tissue EVs and other biogenic nanoparticles (BiNPs) were assessed in terms of altering Toll-like receptor 4 (TLR4)-induced cytokines. TLR-4 signaling in macrophages is often triggered by pathogen or damage-induced inflammation and is associated with several diseases. This study demonstrates that miR-451a, which is abundant in adipose tissue BiNPs, suppresses pro-inflammatory cytokines and increases anti-inflammatory cytokines associated with the TLR4 pathway. Therefore, miR-451a may be partially responsible for immunomodulatory effects of adipose tissue-derived BiNPs.

Original languageEnglish (US)
Article number16
JournalPharmaceutics
Volume14
Issue number1
DOIs
StatePublished - Jan 2022

Keywords

  • Exosome
  • Extracellular vesicle
  • MicroRNA
  • Microvesicle
  • Toll-like receptor 4

ASJC Scopus subject areas

  • Pharmaceutical Science

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