@article{2756f621584b4df8be02152568105750,
title = "Effects of adipose-derived biogenic nanoparticle-associated microrna-451a on toll-like receptor 4-induced cytokines",
abstract = "Extracellular vesicles (EVs) are cell-released nanoparticles that transfer biomolecular content between cells. Among EV-associated biomolecules, microRNAs (miRNAs/miRs) represent one of the most important modulators of signaling pathways in recipient cells. Previous studies have shown that EVs from adipose-derived mesenchymal stromal cells (MSCs) and adipose tissue modulate inflammatory pathways in macrophages. In this study, the effects of miRNAs that are abundant in adipose tissue EVs and other biogenic nanoparticles (BiNPs) were assessed in terms of altering Toll-like receptor 4 (TLR4)-induced cytokines. TLR-4 signaling in macrophages is often triggered by pathogen or damage-induced inflammation and is associated with several diseases. This study demonstrates that miR-451a, which is abundant in adipose tissue BiNPs, suppresses pro-inflammatory cytokines and increases anti-inflammatory cytokines associated with the TLR4 pathway. Therefore, miR-451a may be partially responsible for immunomodulatory effects of adipose tissue-derived BiNPs.",
keywords = "Exosome, Extracellular vesicle, MicroRNA, Microvesicle, Toll-like receptor 4",
author = "Xinghua Wang and Anthony Pham and Lu Kang and Walker, {Sierra A.} and Irina Davidovich and Dalila Iannotta and Terkonda, {Sarvam P.} and Shane Shapiro and Yeshayahu Talmon and Si Pham and Joy Wolfram",
note = "Funding Information: Funding: This work is partially supported by the Mayo Clinic Center for Regenerative Medicine in Florida (J.W., S.P.), the Mayo Clinic Center for Biomedical Discovery (J.W.), the Erik Compton Foundation (S.P.), the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) under award numbers R21AI152318 (J.W.), the American Heart Association under award number 20TPA35490415 (J.W.), and Programma Operativo Nazionale Ricerca e Innovazione, Italian Ministry of Education, University and Research, Italy, under award number DOT13A8025 (D.I., J.W.). The cryo-TEM work was performed at the Technion Center for Electron Microscopy of Soft Matter. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2021",
month = dec,
day = "22",
doi = "10.3390/pharmaceutics14010016",
language = "English (US)",
volume = "14",
journal = "Pharmaceutics",
issn = "1999-4923",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "1",
}