After an acute exposure to lanthanum chloride, the pharmacokinetics of calcium uptake in rats was studied by radioactive 47Ca tracer. The accumulated doses of calcium in the left femurs during 24 hours were determined. The results showed that the area under the curves (AUC), specific activity of maximal blood 47Ca concentration (C max ), distribution rate constant (K a ) and the accumulated dose of calcium in the left femur decreased while time to C max (T peak ) increased with the rising dosage of lanthanum exposure. It indicated that lanthanum expose had a negative effect on calcium absorption.
ASJC Scopus subject areas
- Analytical Chemistry
- Nuclear Energy and Engineering
- Radiology Nuclear Medicine and imaging
- Public Health, Environmental and Occupational Health
- Health, Toxicology and Mutagenesis