Effects of acute lanthanum exposure on calcium absorption in rats

X. He; Z. Y. Zhang; L. X. Feng; Z. J. Li; J. H. Yang; Y. L. Zhao; Z. F. Chai

doi:10.1007/s10967-007-0623-1

Effects of acute lanthanum exposure on calcium absorption in rats

X. He, Z. Y. Zhang, L. X. Feng, Z. J. Li, J. H. Yang, Y. L. Zhao, Z. F. Chai

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4 Scopus citations

Abstract

After an acute exposure to lanthanum chloride, the pharmacokinetics of calcium uptake in rats was studied by radioactive ⁴⁷Ca tracer. The accumulated doses of calcium in the left femurs during 24 hours were determined. The results showed that the area under the curves (AUC), specific activity of maximal blood ⁴⁷Ca concentration (C _max ), distribution rate constant (K _a ) and the accumulated dose of calcium in the left femur decreased while time to C _max (T _peak ) increased with the rising dosage of lanthanum exposure. It indicated that lanthanum expose had a negative effect on calcium absorption.

Original language	English (US)
Pages (from-to)	557-559
Number of pages	3
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	272
Issue number	3
DOIs	https://doi.org/10.1007/s10967-007-0623-1
State	Published - Jun 2007

ASJC Scopus subject areas

Analytical Chemistry
Nuclear Energy and Engineering
Radiology Nuclear Medicine and imaging
Pollution
Spectroscopy
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

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10.1007/s10967-007-0623-1

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title = "Effects of acute lanthanum exposure on calcium absorption in rats",

abstract = "After an acute exposure to lanthanum chloride, the pharmacokinetics of calcium uptake in rats was studied by radioactive 47Ca tracer. The accumulated doses of calcium in the left femurs during 24 hours were determined. The results showed that the area under the curves (AUC), specific activity of maximal blood 47Ca concentration (C max ), distribution rate constant (K a ) and the accumulated dose of calcium in the left femur decreased while time to C max (T peak ) increased with the rising dosage of lanthanum exposure. It indicated that lanthanum expose had a negative effect on calcium absorption.",

author = "X. He and Zhang, {Z. Y.} and Feng, {L. X.} and Li, {Z. J.} and Yang, {J. H.} and Zhao, {Y. L.} and Chai, {Z. F.}",

note = "Funding Information: This work was financially supported by National Natural Science Foundation China (Grant No. 10490181), Chinese Academy of Sciences (KJCX3.SYW.N3), the Ministry of Science and Technology (2006CB705605) and Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics.",

year = "2007",

month = jun,

doi = "10.1007/s10967-007-0623-1",

language = "English (US)",

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journal = "Journal of Radioanalytical and Nuclear Chemistry",

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T1 - Effects of acute lanthanum exposure on calcium absorption in rats

AU - He, X.

AU - Zhang, Z. Y.

AU - Feng, L. X.

AU - Li, Z. J.

AU - Yang, J. H.

AU - Zhao, Y. L.

AU - Chai, Z. F.

N1 - Funding Information: This work was financially supported by National Natural Science Foundation China (Grant No. 10490181), Chinese Academy of Sciences (KJCX3.SYW.N3), the Ministry of Science and Technology (2006CB705605) and Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics.

PY - 2007/6

Y1 - 2007/6

N2 - After an acute exposure to lanthanum chloride, the pharmacokinetics of calcium uptake in rats was studied by radioactive 47Ca tracer. The accumulated doses of calcium in the left femurs during 24 hours were determined. The results showed that the area under the curves (AUC), specific activity of maximal blood 47Ca concentration (C max ), distribution rate constant (K a ) and the accumulated dose of calcium in the left femur decreased while time to C max (T peak ) increased with the rising dosage of lanthanum exposure. It indicated that lanthanum expose had a negative effect on calcium absorption.

AB - After an acute exposure to lanthanum chloride, the pharmacokinetics of calcium uptake in rats was studied by radioactive 47Ca tracer. The accumulated doses of calcium in the left femurs during 24 hours were determined. The results showed that the area under the curves (AUC), specific activity of maximal blood 47Ca concentration (C max ), distribution rate constant (K a ) and the accumulated dose of calcium in the left femur decreased while time to C max (T peak ) increased with the rising dosage of lanthanum exposure. It indicated that lanthanum expose had a negative effect on calcium absorption.

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Effects of acute lanthanum exposure on calcium absorption in rats

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