Effects of 2,3,7,8-TCDD and related compounds on the levels of age-dependent I-spot DNA adducts in the liver of female and male Sprague-Dawley rats

K. Randerath; K. L. Putman; E. Randerath; M. Harris; T. Zacharewski; S. Safe

doi:10.1016/0045-6535(90)90219-J

Effects of 2,3,7,8-TCDD and related compounds on the levels of age-dependent I-spot DNA adducts in the liver of female and male Sprague-Dawley rats

K. Randerath, K. L. Putman, E. Randerath, M. Harris, T. Zacharewski, S. Safe

Research output: Contribution to journal › Article › peer-review

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Abstract

Treatment of adult female rats with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, 1 μg and 5 μg/kg/week) over a period of 4 weeks resulted in a dose-dependent decrease in the levels of hepatic I-compounds (DNA adducts) as determined by the ³²P-postlabeling procedure. In adult male Sprague Dawley rats TCDD did not change the levels of total hepatic I-spots. The significance of these sex-specific effects and other data will be discussed.

Original language	English (US)
Pages (from-to)	1049-1052
Number of pages	4
Journal	Chemosphere
Volume	20
Issue number	7-9
DOIs	https://doi.org/10.1016/0045-6535(90)90219-J
State	Published - 1990

ASJC Scopus subject areas

Environmental Engineering
Environmental Chemistry
Chemistry(all)
Pollution
Health, Toxicology and Mutagenesis

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10.1016/0045-6535(90)90219-J

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@article{b4e294b3298e4706a270dbafc02f7cd0,

title = "Effects of 2,3,7,8-TCDD and related compounds on the levels of age-dependent I-spot DNA adducts in the liver of female and male Sprague-Dawley rats",

abstract = "Treatment of adult female rats with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, 1 μg and 5 μg/kg/week) over a period of 4 weeks resulted in a dose-dependent decrease in the levels of hepatic I-compounds (DNA adducts) as determined by the 32P-postlabeling procedure. In adult male Sprague Dawley rats TCDD did not change the levels of total hepatic I-spots. The significance of these sex-specific effects and other data will be discussed.",

author = "K. Randerath and Putman, {K. L.} and E. Randerath and M. Harris and T. Zacharewski and S. Safe",

note = "Funding Information: ACKNOWLEDGEMENTS The financial assistance of the National Institutes of Health (P42-ES04917 and R37-CA32157) and the U.S. Environmental Protection Agency are gratefully acknowledged. S. Safe is a Burroughs Wellcome Toxicology Scholar. K. Randerath is the recipient of a Du Pont Occupational and Environmental Health grant. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.",

year = "1990",

doi = "10.1016/0045-6535(90)90219-J",

language = "English (US)",

volume = "20",

pages = "1049--1052",

journal = "Chemosphere",

issn = "0045-6535",

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number = "7-9",

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T1 - Effects of 2,3,7,8-TCDD and related compounds on the levels of age-dependent I-spot DNA adducts in the liver of female and male Sprague-Dawley rats

AU - Randerath, K.

AU - Putman, K. L.

AU - Randerath, E.

AU - Harris, M.

AU - Zacharewski, T.

AU - Safe, S.

N1 - Funding Information: ACKNOWLEDGEMENTS The financial assistance of the National Institutes of Health (P42-ES04917 and R37-CA32157) and the U.S. Environmental Protection Agency are gratefully acknowledged. S. Safe is a Burroughs Wellcome Toxicology Scholar. K. Randerath is the recipient of a Du Pont Occupational and Environmental Health grant. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.

PY - 1990

Y1 - 1990

N2 - Treatment of adult female rats with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, 1 μg and 5 μg/kg/week) over a period of 4 weeks resulted in a dose-dependent decrease in the levels of hepatic I-compounds (DNA adducts) as determined by the 32P-postlabeling procedure. In adult male Sprague Dawley rats TCDD did not change the levels of total hepatic I-spots. The significance of these sex-specific effects and other data will be discussed.

AB - Treatment of adult female rats with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, 1 μg and 5 μg/kg/week) over a period of 4 weeks resulted in a dose-dependent decrease in the levels of hepatic I-compounds (DNA adducts) as determined by the 32P-postlabeling procedure. In adult male Sprague Dawley rats TCDD did not change the levels of total hepatic I-spots. The significance of these sex-specific effects and other data will be discussed.

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Effects of 2,3,7,8-TCDD and related compounds on the levels of age-dependent I-spot DNA adducts in the liver of female and male Sprague-Dawley rats

Abstract

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