Abstract
Treatment of adult female rats with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, 1 μg and 5 μg/kg/week) over a period of 4 weeks resulted in a dose-dependent decrease in the levels of hepatic I-compounds (DNA adducts) as determined by the 32P-postlabeling procedure. In adult male Sprague Dawley rats TCDD did not change the levels of total hepatic I-spots. The significance of these sex-specific effects and other data will be discussed.
Original language | English (US) |
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Pages (from-to) | 1049-1052 |
Number of pages | 4 |
Journal | Chemosphere |
Volume | 20 |
Issue number | 7-9 |
DOIs | |
State | Published - 1990 |
ASJC Scopus subject areas
- Environmental Engineering
- Environmental Chemistry
- General Chemistry
- Pollution
- Health, Toxicology and Mutagenesis