Effects of 2,3,7,8-TCDD and related compounds on the levels of age-dependent I-spot DNA adducts in the liver of female and male Sprague-Dawley rats

K. Randerath, K. L. Putman, E. Randerath, M. Harris, T. Zacharewski, S. Safe

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Treatment of adult female rats with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, 1 μg and 5 μg/kg/week) over a period of 4 weeks resulted in a dose-dependent decrease in the levels of hepatic I-compounds (DNA adducts) as determined by the 32P-postlabeling procedure. In adult male Sprague Dawley rats TCDD did not change the levels of total hepatic I-spots. The significance of these sex-specific effects and other data will be discussed.

Original languageEnglish (US)
Pages (from-to)1049-1052
Number of pages4
JournalChemosphere
Volume20
Issue number7-9
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Chemistry
  • Chemistry(all)
  • Pollution
  • Health, Toxicology and Mutagenesis

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