Effector triggered manipulation of host immune response elicited by different pathotypes of escherichia coli

Elamparithi Jayamani, Eleftherios Mylonakis

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Effectors are virulence factors that are secreted by bacteria during an infection in order to subvert cellular processes or induce the surveillance system of the host. Pathogenic microorganisms encode effectors, toxins and components of secretion systems that inject the effectors to the host. Escherichia coli is part of the innocuous commensal microbial flora of the gastrointestinal tract. However, pathogenic E. coli can cause diarrheal and extraintestinal diseases. Pathogenic E. coli uses secretion systems to inject an array of effector proteins directly into the host cells. Herein, we discuss the effectors secreted by different pathotypes of E. coli and provide an overview of strategies employed by effectors to target the host cellular and subcellular processes as well as their role in triggering host immune response.

Original languageEnglish (US)
Pages (from-to)733-739
Number of pages7
JournalVirulence
Volume5
Issue number7
DOIs
StatePublished - 2014

Keywords

  • AIEC
  • EHEC
  • EPEC
  • Effectors
  • IBD
  • Immunity
  • Pathogenic E. coli
  • Type secretion system
  • Virulence

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'Effector triggered manipulation of host immune response elicited by different pathotypes of escherichia coli'. Together they form a unique fingerprint.

Cite this