Effectiveness of the Original Monovalent Messenger RNA Coronavirus Disease 2019 (COVID-19) Vaccination Series Against Hospitalization for COVID-19-Associated Venous Thromboembolism

David N. Hager; Yuwei Zhu; Ine Sohn; William B. Stubblefield; Michael B. Streiff; Manjusha Gaglani; Jay S. Steingrub; Abhijit Duggal; Jamie R. Felzer; Mary O'Rourke; Ithan D. Peltan; Amira Mohamed; Robin Stiller; Jennifer G. Wilson; Nida Qadir; Adit A. Ginde; Anne E. Zepeski; Christopher Mallow; Adam S. Lauring; Nicholas J. Johnson; Kevin W. Gibbs; Jennie H. Kwon; Wesley H. Self; Manjusha Gaglani; Tresa McNeal; Shekhar Ghamande; Nicole Calhoun; Kempapura Murthy; Judy Herrick; Amanda McKillop; Eric Hoffman; Martha Zayed; Michael Smith; Jay Steingrub; Lori Ann Kozikowski; Lesley De Souza; Scott Ouellette; Nathan I. Shapiro; Michael Bolstad; Brianna Coviello; Robert Ciottone; Arnaldo Devilla; Ana Grafals; Conor Higgins; Carlo Ottanelli; Kimberly Redman; Douglas Scaffidi; Alexander Weingart; Diya Surie; Meredith McMorrow; Jennifer Decuir; Natalie Thornburg; Brendan Flannery; Nathaniel Lewis; Mark Tenforde; Katherine Adams; Manish Patel; Omar Mehkri; Megan Mitchell; Zachary Griffith; Connery Brennan; Kiran Ashok; Bryan Poynter; Abhijit Duggal; Laurence Busse; Caitlin Ten Lohuis; Nicholas Stanley; Sophia Zhang; Matthew Prekker; Heidi Erickson; Anne Frosch; Audrey Hendrickson; Sean Caspers; Walker Tordsen; Olivia Kaus; Tyler Scharber; Ithan Peltan; Samuel Brown; Jenna Lumpkin; Cassie Smith; Hunter Marshall; Harith Ali; Michelle Gong; Amira Mohamed; Rahul Nair; Jen Ting Chen; Matthew Exline; Sarah Karow; Emily Robart; Paulo Nunes Maldonado; Maryiam Khan; Preston So; Madison So; Elizabeth Schwartz; Mena Botros; Akram Khan; Catherine L. Hough; Haeun Jung; Jesus Martinez; Andrea Luong; Bao Huynh; Habiba Ibrahim; Cynthia Villanueva-Vargas; Juliana Villanueva-Vargas; Suha Quadri; Jennifer G. Wilson; Alexandra June Gordon; Joe Levitt; Cynthia Perez; Anita Visweswaran; Jonasel Roque; Nida Qadir; Steven Chang; Trevor Frankel; Omai Garner; Sukantha Chandrasekaran; Adit Ginde; David Douin; Kelly Jensen; David Huynh; Aimee Steinwand; Cori Withers; Nicholas Mohr; Anne Zepeski; Paul Nassar; Shannon Landers; Karin Nielsen; Noble Briggs; Cathy Fairfield; Chris Mallow; Carolina Rivas; Emily Martin; Arnold Monto; Adam Lauring; E. J. McSpadden; Rachel Truscon; Anne Kaniclides; Lara Thomas; Ramsay Bielak; Weronika Damek Valvano; Rebecca Fong; William J. Fitzsimmons; Christopher Blair; Julie Gilbert; Leigh Papalambros; Nicholas Johnson; Vasisht Srinivasan; Christine D. Crider; Kyle A. Steinbock; Thomas C. Paulsen; Layla A. Anderson; H. Keipp Talbot; Carlos Grijalva; Ian Jones; Natasha Halasa; James Chappell; Kelsey Womack; Jillian Rhoads; Adrienne Baughman; Christy Kampe; Jakea Johnson; Kim Hart; Todd Rice; Jonathan Casey; William B. Stubblefield; Yuwei Zhu; Laura L. Short; Lauren J. Ezzell; Margaret E. Whitsett; Rendie E. McHenry; Samarian J. Hargrave; Marcia Blair; Jennifer L. Luther; Claudia Guevara Pulido; Bryan P.M. Peterson; D. Clark Files; Kevin Gibbs; Mary Larose; Leigha Landreth; Madeline Hicks; Lisa Parks; Hilary Babcock; Jahnavi Bongu; David McDonald; Candice Cass; Sondra Seiler; David Park; Tiffany Hink; Meghan Wallace; Carey Ann Burnham; Olivia G. Arter

doi:10.1093/infdis/jiae502

Effectiveness of the Original Monovalent Messenger RNA Coronavirus Disease 2019 (COVID-19) Vaccination Series Against Hospitalization for COVID-19-Associated Venous Thromboembolism

David N. Hager, Yuwei Zhu, Ine Sohn, William B. Stubblefield, Michael B. Streiff, Manjusha Gaglani, Jay S. Steingrub, Abhijit Duggal, Jamie R. Felzer, Mary O'Rourke, Ithan D. Peltan, Amira Mohamed, Robin Stiller, Jennifer G. Wilson, Nida Qadir, Adit A. Ginde, Anne E. Zepeski, Christopher Mallow, Adam S. Lauring, Nicholas J. JohnsonKevin W. Gibbs, Jennie H. Kwon, Wesley H. Self, Manjusha Gaglani, Tresa McNeal, Shekhar Ghamande, Nicole Calhoun, Kempapura Murthy, Judy Herrick, Amanda McKillop, Eric Hoffman, Martha Zayed, Michael Smith, Jay Steingrub, Lori Ann Kozikowski, Lesley De Souza, Scott Ouellette, Nathan I. Shapiro, Michael Bolstad, Brianna Coviello, Robert Ciottone, Arnaldo Devilla, Ana Grafals, Conor Higgins, Carlo Ottanelli, Kimberly Redman, Douglas Scaffidi, Alexander Weingart, Diya Surie, Meredith McMorrow, Jennifer Decuir, Natalie Thornburg, Brendan Flannery, Nathaniel Lewis, Mark Tenforde, Katherine Adams, Manish Patel, Omar Mehkri, Megan Mitchell, Zachary Griffith, Connery Brennan, Kiran Ashok, Bryan Poynter, Abhijit Duggal, Laurence Busse, Caitlin Ten Lohuis, Nicholas Stanley, Sophia Zhang, Matthew Prekker, Heidi Erickson, Anne Frosch, Audrey Hendrickson, Sean Caspers, Walker Tordsen, Olivia Kaus, Tyler Scharber, Ithan Peltan, Samuel Brown, Jenna Lumpkin, Cassie Smith, Hunter Marshall, Harith Ali, Michelle Gong, Amira Mohamed, Rahul Nair, Jen Ting Chen, Matthew Exline, Sarah Karow, Emily Robart, Paulo Nunes Maldonado, Maryiam Khan, Preston So, Madison So, Elizabeth Schwartz, Mena Botros, Akram Khan, Catherine L. Hough, Haeun Jung, Jesus Martinez, Andrea Luong, Bao Huynh, Habiba Ibrahim, Cynthia Villanueva-Vargas, Juliana Villanueva-Vargas, Suha Quadri, Jennifer G. Wilson, Alexandra June Gordon, Joe Levitt, Cynthia Perez, Anita Visweswaran, Jonasel Roque, Nida Qadir, Steven Chang, Trevor Frankel, Omai Garner, Sukantha Chandrasekaran, Adit Ginde, David Douin, Kelly Jensen, David Huynh, Aimee Steinwand, Cori Withers, Nicholas Mohr, Anne Zepeski, Paul Nassar, Shannon Landers, Karin Nielsen, Noble Briggs, Cathy Fairfield, Chris Mallow, Carolina Rivas, Emily Martin, Arnold Monto, Adam Lauring, E. J. McSpadden, Rachel Truscon, Anne Kaniclides, Lara Thomas, Ramsay Bielak, Weronika Damek Valvano, Rebecca Fong, William J. Fitzsimmons, Christopher Blair, Julie Gilbert, Leigh Papalambros, Nicholas Johnson, Vasisht Srinivasan, Christine D. Crider, Kyle A. Steinbock, Thomas C. Paulsen, Layla A. Anderson, H. Keipp Talbot, Carlos Grijalva, Ian Jones, Natasha Halasa, James Chappell, Kelsey Womack, Jillian Rhoads, Adrienne Baughman, Christy Kampe, Jakea Johnson, Kim Hart, Todd Rice, Jonathan Casey, William B. Stubblefield, Yuwei Zhu, Laura L. Short, Lauren J. Ezzell, Margaret E. Whitsett, Rendie E. McHenry, Samarian J. Hargrave, Marcia Blair, Jennifer L. Luther, Claudia Guevara Pulido, Bryan P.M. Peterson, D. Clark Files, Kevin Gibbs, Mary Larose, Leigha Landreth, Madeline Hicks, Lisa Parks, Hilary Babcock, Jahnavi Bongu, David McDonald, Candice Cass, Sondra Seiler, David Park, Tiffany Hink, Meghan Wallace, Carey Ann Burnham, Olivia G. Arter

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Coronavirus disease 2019 (COVID-19) is a strong risk factor for venous thromboembolism (VTE). Few studies have evaluated the effectiveness of COVID-19 vaccination in preventing hospitalization for COVID-19 with VTE. Methods: Adults hospitalized at 21 sites between March 2021 and October 2022 with symptoms of acute respiratory illness were assessed for COVID-19, completion of the original monovalent messenger RNA (mRNA) COVID-19 vaccination series, and VTE. Prevalence of VTE was compared between unvaccinated and vaccinated patients with COVID-19. The vaccine effectiveness (VE) in preventing COVID-19 hospitalization with VTE was calculated using a test-negative design. The VE was also stratified by predominant circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant. Results: Among 18 811 patients (median age [interquartile range], 63 [50-73] years; 49% women; 59% non-Hispanic white, 20% non-Hispanic black, and 14% Hispanic; and median of 2 comorbid conditions [interquartile range, 1-3]), 9792 were admitted with COVID-19 (44% vaccinated), and 9019 were test-negative controls (73% vaccinated). Among patients with COVID-19, 601 had VTE diagnosed by hospital day 28, of whom 170 were vaccinated. VTE was more common among unvaccinated than vaccinated patients with COVID-19 (7.8% vs 4.0%; P =. 001). The VE against COVID-19 hospitalization with VTE was 84% overall (95% confidence interval, 80%-87%), and VE stratified by predominant circulating variant was 88% (73%-95%) for Alpha, 93% (90%-95%) for Delta, and 68% (58%-76%) for Omicron variants. Conclusions: Vaccination with the original monovalent mRNA series was associated with a decrease in COVID-19 hospitalization with VTE, though data detailing prior history of VTE and use of anticoagulation were not available. These findings will inform risk-benefit considerations for those considering vaccination.

Original language	English (US)
Pages (from-to)	378-385
Number of pages	8
Journal	Journal of Infectious Diseases
Volume	231
Issue number	2
DOIs	https://doi.org/10.1093/infdis/jiae502
State	Published - Feb 15 2025

Keywords

COVID-19
SARS-CoV-2
vaccine
venous thromboembolism

ASJC Scopus subject areas

General Medicine

Access to Document

10.1093/infdis/jiae502

Cite this

Hager, D. N., Zhu, Y., Sohn, I., Stubblefield, W. B., Streiff, M. B., Gaglani, M., Steingrub, J. S., Duggal, A., Felzer, J. R., O'Rourke, M., Peltan, I. D., Mohamed, A., Stiller, R., Wilson, J. G., Qadir, N., Ginde, A. A., Zepeski, A. E., Mallow, C., Lauring, A. S., ... Arter, O. G. (2025). Effectiveness of the Original Monovalent Messenger RNA Coronavirus Disease 2019 (COVID-19) Vaccination Series Against Hospitalization for COVID-19-Associated Venous Thromboembolism. Journal of Infectious Diseases, 231(2), 378-385. https://doi.org/10.1093/infdis/jiae502

Effectiveness of the Original Monovalent Messenger RNA Coronavirus Disease 2019 (COVID-19) Vaccination Series Against Hospitalization for COVID-19-Associated Venous Thromboembolism. / Hager, David N.; Zhu, Yuwei; Sohn, Ine et al.
In: Journal of Infectious Diseases, Vol. 231, No. 2, 15.02.2025, p. 378-385.

Research output: Contribution to journal › Article › peer-review

Hager, DN, Zhu, Y, Sohn, I, Stubblefield, WB, Streiff, MB, Gaglani, M, Steingrub, JS, Duggal, A, Felzer, JR, O'Rourke, M, Peltan, ID, Mohamed, A, Stiller, R, Wilson, JG, Qadir, N, Ginde, AA, Zepeski, AE, Mallow, C, Lauring, AS, Johnson, NJ, Gibbs, KW, Kwon, JH, Self, WH, Gaglani, M, McNeal, T, Ghamande, S, Calhoun, N, Murthy, K, Herrick, J, McKillop, A, Hoffman, E, Zayed, M, Smith, M, Steingrub, J, Kozikowski, LA, De Souza, L, Ouellette, S, Shapiro, NI, Bolstad, M, Coviello, B, Ciottone, R, Devilla, A, Grafals, A, Higgins, C, Ottanelli, C, Redman, K, Scaffidi, D, Weingart, A, Surie, D, McMorrow, M, Decuir, J, Thornburg, N, Flannery, B, Lewis, N, Tenforde, M, Adams, K, Patel, M, Mehkri, O, Mitchell, M, Griffith, Z, Brennan, C, Ashok, K, Poynter, B, Duggal, A, Busse, L, Ten Lohuis, C, Stanley, N, Zhang, S, Prekker, M, Erickson, H, Frosch, A, Hendrickson, A, Caspers, S, Tordsen, W, Kaus, O, Scharber, T, Peltan, I, Brown, S, Lumpkin, J, Smith, C, Marshall, H, Ali, H, Gong, M, Mohamed, A, Nair, R, Chen, JT, Exline, M, Karow, S, Robart, E, Maldonado, PN, Khan, M, So, P, So, M, Schwartz, E, Botros, M, Khan, A, Hough, CL, Jung, H, Martinez, J, Luong, A, Huynh, B, Ibrahim, H, Villanueva-Vargas, C, Villanueva-Vargas, J, Quadri, S, Wilson, JG, Gordon, AJ, Levitt, J, Perez, C, Visweswaran, A, Roque, J, Qadir, N, Chang, S, Frankel, T, Garner, O, Chandrasekaran, S, Ginde, A, Douin, D, Jensen, K, Huynh, D, Steinwand, A, Withers, C, Mohr, N, Zepeski, A, Nassar, P, Landers, S, Nielsen, K, Briggs, N, Fairfield, C, Mallow, C, Rivas, C, Martin, E, Monto, A, Lauring, A, McSpadden, EJ, Truscon, R, Kaniclides, A, Thomas, L, Bielak, R, Valvano, WD, Fong, R, Fitzsimmons, WJ, Blair, C, Gilbert, J, Papalambros, L, Johnson, N, Srinivasan, V, Crider, CD, Steinbock, KA, Paulsen, TC, Anderson, LA, Talbot, HK, Grijalva, C, Jones, I, Halasa, N, Chappell, J, Womack, K, Rhoads, J, Baughman, A, Kampe, C, Johnson, J, Hart, K, Rice, T, Casey, J, Stubblefield, WB, Zhu, Y, Short, LL, Ezzell, LJ, Whitsett, ME, McHenry, RE, Hargrave, SJ, Blair, M, Luther, JL, Pulido, CG, Peterson, BPM, Files, DC, Gibbs, K, Larose, M, Landreth, L, Hicks, M, Parks, L, Babcock, H, Bongu, J, McDonald, D, Cass, C, Seiler, S, Park, D, Hink, T, Wallace, M, Burnham, CA & Arter, OG 2025, 'Effectiveness of the Original Monovalent Messenger RNA Coronavirus Disease 2019 (COVID-19) Vaccination Series Against Hospitalization for COVID-19-Associated Venous Thromboembolism', Journal of Infectious Diseases, vol. 231, no. 2, pp. 378-385. https://doi.org/10.1093/infdis/jiae502

@article{ac97e460f24b422cb93f039f25815960,

title = "Effectiveness of the Original Monovalent Messenger RNA Coronavirus Disease 2019 (COVID-19) Vaccination Series Against Hospitalization for COVID-19-Associated Venous Thromboembolism",

abstract = "Background: Coronavirus disease 2019 (COVID-19) is a strong risk factor for venous thromboembolism (VTE). Few studies have evaluated the effectiveness of COVID-19 vaccination in preventing hospitalization for COVID-19 with VTE. Methods: Adults hospitalized at 21 sites between March 2021 and October 2022 with symptoms of acute respiratory illness were assessed for COVID-19, completion of the original monovalent messenger RNA (mRNA) COVID-19 vaccination series, and VTE. Prevalence of VTE was compared between unvaccinated and vaccinated patients with COVID-19. The vaccine effectiveness (VE) in preventing COVID-19 hospitalization with VTE was calculated using a test-negative design. The VE was also stratified by predominant circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant. Results: Among 18 811 patients (median age [interquartile range], 63 [50-73] years; 49% women; 59% non-Hispanic white, 20% non-Hispanic black, and 14% Hispanic; and median of 2 comorbid conditions [interquartile range, 1-3]), 9792 were admitted with COVID-19 (44% vaccinated), and 9019 were test-negative controls (73% vaccinated). Among patients with COVID-19, 601 had VTE diagnosed by hospital day 28, of whom 170 were vaccinated. VTE was more common among unvaccinated than vaccinated patients with COVID-19 (7.8% vs 4.0%; P =. 001). The VE against COVID-19 hospitalization with VTE was 84% overall (95% confidence interval, 80%-87%), and VE stratified by predominant circulating variant was 88% (73%-95%) for Alpha, 93% (90%-95%) for Delta, and 68% (58%-76%) for Omicron variants. Conclusions: Vaccination with the original monovalent mRNA series was associated with a decrease in COVID-19 hospitalization with VTE, though data detailing prior history of VTE and use of anticoagulation were not available. These findings will inform risk-benefit considerations for those considering vaccination.",

keywords = "COVID-19, SARS-CoV-2, vaccine, venous thromboembolism",

author = "Hager, {David N.} and Yuwei Zhu and Ine Sohn and Stubblefield, {William B.} and Streiff, {Michael B.} and Manjusha Gaglani and Steingrub, {Jay S.} and Abhijit Duggal and Felzer, {Jamie R.} and Mary O'Rourke and Peltan, {Ithan D.} and Amira Mohamed and Robin Stiller and Wilson, {Jennifer G.} and Nida Qadir and Ginde, {Adit A.} and Zepeski, {Anne E.} and Christopher Mallow and Lauring, {Adam S.} and Johnson, {Nicholas J.} and Gibbs, {Kevin W.} and Kwon, {Jennie H.} and Self, {Wesley H.} and Manjusha Gaglani and Tresa McNeal and Shekhar Ghamande and Nicole Calhoun and Kempapura Murthy and Judy Herrick and Amanda McKillop and Eric Hoffman and Martha Zayed and Michael Smith and Jay Steingrub and Kozikowski, {Lori Ann} and {De Souza}, Lesley and Scott Ouellette and Shapiro, {Nathan I.} and Michael Bolstad and Brianna Coviello and Robert Ciottone and Arnaldo Devilla and Ana Grafals and Conor Higgins and Carlo Ottanelli and Kimberly Redman and Douglas Scaffidi and Alexander Weingart and Diya Surie and Meredith McMorrow and Jennifer Decuir and Natalie Thornburg and Brendan Flannery and Nathaniel Lewis and Mark Tenforde and Katherine Adams and Manish Patel and Omar Mehkri and Megan Mitchell and Zachary Griffith and Connery Brennan and Kiran Ashok and Bryan Poynter and Abhijit Duggal and Laurence Busse and {Ten Lohuis}, Caitlin and Nicholas Stanley and Sophia Zhang and Matthew Prekker and Heidi Erickson and Anne Frosch and Audrey Hendrickson and Sean Caspers and Walker Tordsen and Olivia Kaus and Tyler Scharber and Ithan Peltan and Samuel Brown and Jenna Lumpkin and Cassie Smith and Hunter Marshall and Harith Ali and Michelle Gong and Amira Mohamed and Rahul Nair and Chen, {Jen Ting} and Matthew Exline and Sarah Karow and Emily Robart and Maldonado, {Paulo Nunes} and Maryiam Khan and Preston So and Madison So and Elizabeth Schwartz and Mena Botros and Akram Khan and Hough, {Catherine L.} and Haeun Jung and Jesus Martinez and Andrea Luong and Bao Huynh and Habiba Ibrahim and Cynthia Villanueva-Vargas and Juliana Villanueva-Vargas and Suha Quadri and Wilson, {Jennifer G.} and Gordon, {Alexandra June} and Joe Levitt and Cynthia Perez and Anita Visweswaran and Jonasel Roque and Nida Qadir and Steven Chang and Trevor Frankel and Omai Garner and Sukantha Chandrasekaran and Adit Ginde and David Douin and Kelly Jensen and David Huynh and Aimee Steinwand and Cori Withers and Nicholas Mohr and Anne Zepeski and Paul Nassar and Shannon Landers and Karin Nielsen and Noble Briggs and Cathy Fairfield and Chris Mallow and Carolina Rivas and Emily Martin and Arnold Monto and Adam Lauring and McSpadden, {E. J.} and Rachel Truscon and Anne Kaniclides and Lara Thomas and Ramsay Bielak and Valvano, {Weronika Damek} and Rebecca Fong and Fitzsimmons, {William J.} and Christopher Blair and Julie Gilbert and Leigh Papalambros and Nicholas Johnson and Vasisht Srinivasan and Crider, {Christine D.} and Steinbock, {Kyle A.} and Paulsen, {Thomas C.} and Anderson, {Layla A.} and Talbot, {H. Keipp} and Carlos Grijalva and Ian Jones and Natasha Halasa and James Chappell and Kelsey Womack and Jillian Rhoads and Adrienne Baughman and Christy Kampe and Jakea Johnson and Kim Hart and Todd Rice and Jonathan Casey and Stubblefield, {William B.} and Yuwei Zhu and Short, {Laura L.} and Ezzell, {Lauren J.} and Whitsett, {Margaret E.} and McHenry, {Rendie E.} and Hargrave, {Samarian J.} and Marcia Blair and Luther, {Jennifer L.} and Pulido, {Claudia Guevara} and Peterson, {Bryan P.M.} and Files, {D. Clark} and Kevin Gibbs and Mary Larose and Leigha Landreth and Madeline Hicks and Lisa Parks and Hilary Babcock and Jahnavi Bongu and David McDonald and Candice Cass and Sondra Seiler and David Park and Tiffany Hink and Meghan Wallace and Burnham, {Carey Ann} and Arter, {Olivia G.}",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s).",

year = "2025",

month = feb,

day = "15",

doi = "10.1093/infdis/jiae502",

language = "English (US)",

volume = "231",

pages = "378--385",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "2",

}

TY - JOUR

T1 - Effectiveness of the Original Monovalent Messenger RNA Coronavirus Disease 2019 (COVID-19) Vaccination Series Against Hospitalization for COVID-19-Associated Venous Thromboembolism

AU - Hager, David N.

AU - Zhu, Yuwei

AU - Sohn, Ine

AU - Stubblefield, William B.

AU - Streiff, Michael B.

AU - Gaglani, Manjusha

AU - Steingrub, Jay S.

AU - Duggal, Abhijit

AU - Felzer, Jamie R.

AU - O'Rourke, Mary

AU - Peltan, Ithan D.

AU - Mohamed, Amira

AU - Stiller, Robin

AU - Wilson, Jennifer G.

AU - Qadir, Nida

AU - Ginde, Adit A.

AU - Zepeski, Anne E.

AU - Mallow, Christopher

AU - Lauring, Adam S.

AU - Johnson, Nicholas J.

AU - Gibbs, Kevin W.

AU - Kwon, Jennie H.

AU - Self, Wesley H.

AU - Gaglani, Manjusha

AU - McNeal, Tresa

AU - Ghamande, Shekhar

AU - Calhoun, Nicole

AU - Murthy, Kempapura

AU - Herrick, Judy

AU - McKillop, Amanda

AU - Hoffman, Eric

AU - Zayed, Martha

AU - Smith, Michael

AU - Steingrub, Jay

AU - Kozikowski, Lori Ann

AU - De Souza, Lesley

AU - Ouellette, Scott

AU - Shapiro, Nathan I.

AU - Bolstad, Michael

AU - Coviello, Brianna

AU - Ciottone, Robert

AU - Devilla, Arnaldo

AU - Grafals, Ana

AU - Higgins, Conor

AU - Ottanelli, Carlo

AU - Redman, Kimberly

AU - Scaffidi, Douglas

AU - Weingart, Alexander

AU - Surie, Diya

AU - McMorrow, Meredith

AU - Decuir, Jennifer

AU - Thornburg, Natalie

AU - Flannery, Brendan

AU - Lewis, Nathaniel

AU - Tenforde, Mark

AU - Adams, Katherine

AU - Patel, Manish

AU - Mehkri, Omar

AU - Mitchell, Megan

AU - Griffith, Zachary

AU - Brennan, Connery

AU - Ashok, Kiran

AU - Poynter, Bryan

AU - Duggal, Abhijit

AU - Busse, Laurence

AU - Ten Lohuis, Caitlin

AU - Stanley, Nicholas

AU - Zhang, Sophia

AU - Prekker, Matthew

AU - Erickson, Heidi

AU - Frosch, Anne

AU - Hendrickson, Audrey

AU - Caspers, Sean

AU - Tordsen, Walker

AU - Kaus, Olivia

AU - Scharber, Tyler

AU - Peltan, Ithan

AU - Brown, Samuel

AU - Lumpkin, Jenna

AU - Smith, Cassie

AU - Marshall, Hunter

AU - Ali, Harith

AU - Gong, Michelle

AU - Mohamed, Amira

AU - Nair, Rahul

AU - Chen, Jen Ting

AU - Exline, Matthew

AU - Karow, Sarah

AU - Robart, Emily

AU - Maldonado, Paulo Nunes

AU - Khan, Maryiam

AU - So, Preston

AU - So, Madison

AU - Schwartz, Elizabeth

AU - Botros, Mena

AU - Khan, Akram

AU - Hough, Catherine L.

AU - Jung, Haeun

AU - Martinez, Jesus

AU - Luong, Andrea

AU - Huynh, Bao

AU - Ibrahim, Habiba

AU - Villanueva-Vargas, Cynthia

AU - Villanueva-Vargas, Juliana

AU - Quadri, Suha

AU - Wilson, Jennifer G.

AU - Gordon, Alexandra June

AU - Levitt, Joe

AU - Perez, Cynthia

AU - Visweswaran, Anita

AU - Roque, Jonasel

AU - Qadir, Nida

AU - Chang, Steven

AU - Frankel, Trevor

AU - Garner, Omai

AU - Chandrasekaran, Sukantha

AU - Ginde, Adit

AU - Douin, David

AU - Jensen, Kelly

AU - Huynh, David

AU - Steinwand, Aimee

AU - Withers, Cori

AU - Mohr, Nicholas

AU - Zepeski, Anne

AU - Nassar, Paul

AU - Landers, Shannon

AU - Nielsen, Karin

AU - Briggs, Noble

AU - Fairfield, Cathy

AU - Mallow, Chris

AU - Rivas, Carolina

AU - Martin, Emily

AU - Monto, Arnold

AU - Lauring, Adam

AU - McSpadden, E. J.

AU - Truscon, Rachel

AU - Kaniclides, Anne

AU - Thomas, Lara

AU - Bielak, Ramsay

AU - Valvano, Weronika Damek

AU - Fong, Rebecca

AU - Fitzsimmons, William J.

AU - Blair, Christopher

AU - Gilbert, Julie

AU - Papalambros, Leigh

AU - Johnson, Nicholas

AU - Srinivasan, Vasisht

AU - Crider, Christine D.

AU - Steinbock, Kyle A.

AU - Paulsen, Thomas C.

AU - Anderson, Layla A.

AU - Talbot, H. Keipp

AU - Grijalva, Carlos

AU - Jones, Ian

AU - Halasa, Natasha

AU - Chappell, James

AU - Womack, Kelsey

AU - Rhoads, Jillian

AU - Baughman, Adrienne

AU - Kampe, Christy

AU - Johnson, Jakea

AU - Hart, Kim

AU - Rice, Todd

AU - Casey, Jonathan

AU - Stubblefield, William B.

AU - Zhu, Yuwei

AU - Short, Laura L.

AU - Ezzell, Lauren J.

AU - Whitsett, Margaret E.

AU - McHenry, Rendie E.

AU - Hargrave, Samarian J.

AU - Blair, Marcia

AU - Luther, Jennifer L.

AU - Pulido, Claudia Guevara

AU - Peterson, Bryan P.M.

AU - Files, D. Clark

AU - Gibbs, Kevin

AU - Larose, Mary

AU - Landreth, Leigha

AU - Hicks, Madeline

AU - Parks, Lisa

AU - Babcock, Hilary

AU - Bongu, Jahnavi

AU - McDonald, David

AU - Cass, Candice

AU - Seiler, Sondra

AU - Park, David

AU - Hink, Tiffany

AU - Wallace, Meghan

AU - Burnham, Carey Ann

AU - Arter, Olivia G.

PY - 2025/2/15

Y1 - 2025/2/15

N2 - Background: Coronavirus disease 2019 (COVID-19) is a strong risk factor for venous thromboembolism (VTE). Few studies have evaluated the effectiveness of COVID-19 vaccination in preventing hospitalization for COVID-19 with VTE. Methods: Adults hospitalized at 21 sites between March 2021 and October 2022 with symptoms of acute respiratory illness were assessed for COVID-19, completion of the original monovalent messenger RNA (mRNA) COVID-19 vaccination series, and VTE. Prevalence of VTE was compared between unvaccinated and vaccinated patients with COVID-19. The vaccine effectiveness (VE) in preventing COVID-19 hospitalization with VTE was calculated using a test-negative design. The VE was also stratified by predominant circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant. Results: Among 18 811 patients (median age [interquartile range], 63 [50-73] years; 49% women; 59% non-Hispanic white, 20% non-Hispanic black, and 14% Hispanic; and median of 2 comorbid conditions [interquartile range, 1-3]), 9792 were admitted with COVID-19 (44% vaccinated), and 9019 were test-negative controls (73% vaccinated). Among patients with COVID-19, 601 had VTE diagnosed by hospital day 28, of whom 170 were vaccinated. VTE was more common among unvaccinated than vaccinated patients with COVID-19 (7.8% vs 4.0%; P =. 001). The VE against COVID-19 hospitalization with VTE was 84% overall (95% confidence interval, 80%-87%), and VE stratified by predominant circulating variant was 88% (73%-95%) for Alpha, 93% (90%-95%) for Delta, and 68% (58%-76%) for Omicron variants. Conclusions: Vaccination with the original monovalent mRNA series was associated with a decrease in COVID-19 hospitalization with VTE, though data detailing prior history of VTE and use of anticoagulation were not available. These findings will inform risk-benefit considerations for those considering vaccination.

AB - Background: Coronavirus disease 2019 (COVID-19) is a strong risk factor for venous thromboembolism (VTE). Few studies have evaluated the effectiveness of COVID-19 vaccination in preventing hospitalization for COVID-19 with VTE. Methods: Adults hospitalized at 21 sites between March 2021 and October 2022 with symptoms of acute respiratory illness were assessed for COVID-19, completion of the original monovalent messenger RNA (mRNA) COVID-19 vaccination series, and VTE. Prevalence of VTE was compared between unvaccinated and vaccinated patients with COVID-19. The vaccine effectiveness (VE) in preventing COVID-19 hospitalization with VTE was calculated using a test-negative design. The VE was also stratified by predominant circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant. Results: Among 18 811 patients (median age [interquartile range], 63 [50-73] years; 49% women; 59% non-Hispanic white, 20% non-Hispanic black, and 14% Hispanic; and median of 2 comorbid conditions [interquartile range, 1-3]), 9792 were admitted with COVID-19 (44% vaccinated), and 9019 were test-negative controls (73% vaccinated). Among patients with COVID-19, 601 had VTE diagnosed by hospital day 28, of whom 170 were vaccinated. VTE was more common among unvaccinated than vaccinated patients with COVID-19 (7.8% vs 4.0%; P =. 001). The VE against COVID-19 hospitalization with VTE was 84% overall (95% confidence interval, 80%-87%), and VE stratified by predominant circulating variant was 88% (73%-95%) for Alpha, 93% (90%-95%) for Delta, and 68% (58%-76%) for Omicron variants. Conclusions: Vaccination with the original monovalent mRNA series was associated with a decrease in COVID-19 hospitalization with VTE, though data detailing prior history of VTE and use of anticoagulation were not available. These findings will inform risk-benefit considerations for those considering vaccination.

KW - COVID-19

KW - SARS-CoV-2

KW - vaccine

KW - venous thromboembolism

UR - http://www.scopus.com/inward/record.url?scp=85218975273&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85218975273&partnerID=8YFLogxK

U2 - 10.1093/infdis/jiae502

DO - 10.1093/infdis/jiae502

M3 - Article

C2 - 39405261

AN - SCOPUS:85218975273

SN - 0022-1899

VL - 231

SP - 378

EP - 385

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 2

ER -

Effectiveness of the Original Monovalent Messenger RNA Coronavirus Disease 2019 (COVID-19) Vaccination Series Against Hospitalization for COVID-19-Associated Venous Thromboembolism

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