Effectiveness of an oxidized cellulose patch hemostatic agent in thyroid surgery: A prospective, randomized, controlled study

Moran Amit, Yoav Binenbaum, Jacob T. Cohen, Ziv Gil

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Background: This single-blinded, prospective, randomized controlled trial compared the efficacy and safety of an oxidized cellulose patch (Surgicel [Johnson and Johnson]) with conventional procedures for achieving hemostasis in thyroid surgery. Study Design: The study included 190 patients scheduled for thyroidectomy. Patients were randomized into 1 conventionally treated (ligatures and bipolar electrocautery) group (n = 92) and a second group, which additionally received Surgicel (n = 98). Results: The groups were demographically and clinically matched and had similar wound drainage volumes and mean duration of surgery. Postoperative bleeding rate was greater in the Surgicel group, yet the difference didn't reach statistical significance (p = 0.054). There were no significant group differences in postoperative wound infection, seroma, hypocalcemia, or recurrent laryngeal nerve palsy. Time to drain removal and length of hospital stay were significantly shorter in the conventional group (p < 0.001). Conclusions: Routine use of an oxidized cellulose hemostatic agent has no advantage over conventional hemostasis and is potentially harmful in thyroid surgery.

Original languageEnglish (US)
Pages (from-to)221-225
Number of pages5
JournalJournal of the American College of Surgeons
Volume217
Issue number2
DOIs
StatePublished - Jan 1 2013

ASJC Scopus subject areas

  • Surgery

Fingerprint Dive into the research topics of 'Effectiveness of an oxidized cellulose patch hemostatic agent in thyroid surgery: A prospective, randomized, controlled study'. Together they form a unique fingerprint.

Cite this