Effect of Uridine on Response of 5-Azacytidine-resistant Human Leukemic Cells to Inhibitors of de Novo Pyrimidine Synthesis

Keyphrases

• Leukemic Cells 100%
• Pyrimidine Biosynthesis 100%
• Uridine 100%
• 5-azacytidine 100%
• HL-60 Cells 30%
• Resistant Cells 30%
• Arabinofuranosylcytosine 20%
• Pyrimidine 20%
• Colony Formation 20%
• Uridine-cytidine Kinase 20%
• Cell Growth 10%
• Normal Human 10%
• In Vitro Study 10%
• Leukemia 10%
• Human Bone Marrow 10%
• Colony Forming Units 10%
• Growth Inhibition 10%
• Intracellular Accumulation 10%
• Granulocyte Macrophages 10%
• Bone Marrow Progenitor Cells 10%
• Biochemical Changes 10%
• Parental Lines 10%
• Cross-resistance 10%
• Promyelocytic 10%
• D-ribose 10%
• L-aspartate 10%
• Nucleoside Triphosphates 10%
• Naturally Occurring nucleoside 10%
• 5-fluorouridine 10%
• Pyrimidine Salvage Pathway 10%
• Antileukemic Agents 10%
• Pyrimidine nucleoside 10%
• 6-Azauridine 10%
• Pyrazofurin 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Uridine 100%
• Pyrimidine 100%
• Azacitidine 100%
• Cytarabine 25%
• Uridine Kinase 25%
• Normal Human 12%
• Antileukemic Agent 12%
• Nucleoside 12%
• Aspartic Acid 12%
• Azauridine 12%
• Cross-Resistance 12%
• Pyrimidine Antagonist 12%
• Ribose 12%
• Pirazofurin 12%
• 3 Deazauridine 12%
• Fluorouridine 12%
• Nucleoside Triphosphate 12%
• Pyrimidine Nucleoside 12%

Chemistry

• Uridine 100%
• 5-Azacytidine 100%
• formation 25%
• Cytidine 25%
• Cytarabine 25%
• Ribonucleic Acid 12%
• Nucleoside 12%
• Aspartic Acid 12%
• D-Ribose 12%
• Pyrimidine Nucleoside Triphosphate 12%
• Pyrimidine Antagonist 12%
• Aspartate 12%
• 6-Azauridine 12%
• Percent Reduction 12%
• 5-Fluorouridine 12%
• Antileukemic Agent 12%