Effect of Triglyceride Levels on Methyl and Methylene Envelope Line Widths in Proton Nuclear Magnetic Resonance Spectroscopy of Human Plasma

Eric T. Fossel, Frederick E. Evans, Robert A. Levine, Paul G. Okunieff, Martha P. Mims, Joel D. Morrisett, Antonio Gotto

Research output: Contribution to journalLetter

5 Scopus citations

Abstract

To the Editor: Since the publication of our article in the Journal1 it has become apparent that hypertriglyceridemia can cause false positive results when our method of detecting cancer by water-suppressed proton nuclear magnetic resonance spectroscopy of plasma is used.23 Mims et al. have recently reemphasized this important fact.4 When this became apparent, we developed a new method to distinguish positive results due to hypertriglyceridemia from those due to cancer. This method is based on C-13 nuclear magnetic resonance spectroscopy of the same plasma sample.5 It is our experience and that of other groups23 that triglyceride levels of 190.

Original languageEnglish (US)
Pages (from-to)1409-1412
Number of pages4
JournalNew England Journal of Medicine
Volume321
Issue number20
DOIs
StatePublished - Nov 16 1989

ASJC Scopus subject areas

  • Medicine(all)

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