Ten per cent formaldehyde was instilled into the bladders of 13 mongrel dogs. Nine of the 13 dogs had detectable amounts of formaldehyde in their serum thirty minutes later. In 1 dog spontaneous gangrene and perforation of the bladder developed, and 3 others died of related causes within three weeks. Histologic examination of the bladder was abnormal in all but 2 dogs. The chronic effects of topical formaldehyde appeared to be dystrophic calcification within the bladder wall.
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