TY - JOUR
T1 - Effect of subthalamic nucleus or globus pallidus interna stimulation on oculomotor function in patients with parkinson's disease
AU - Fridley, Jared
AU - Adams, Gareth
AU - Sun, Ping
AU - York, Michelle
AU - Atassi, Farah
AU - Lai, Eugene C.
AU - Simpson, Richard
AU - Viswanathan, Ashwin
AU - Yoshor, Daniel
PY - 2013/3
Y1 - 2013/3
N2 - Background: Deep brain stimulation (DBS) of either the globus pallidus interna (GPi) or subthalamic nucleus (STN) is similarly effective for treating somatomotor manifestations of Parkinson's disease (PD), but differences in how stimulation of each target affects oculomotor function are poorly understood. Objective: We sought to determine if stimulation of the STN, but not the GPi, affects oculomotor function in PD patients. Methods: Nineteen PD patients with DBS implants (8 bilateral GPi, 9 bilateral STN and 2 unilateral STN) were studied. Testing was performed with stimulation on, then off. Somatomotor function was tested using the Unified Parkinson's Disease Rating Scale (UPDRS) motor exam. For oculomotor testing, patients performed pro- and antisaccade tasks while monitored with an infrared eye tracker. Saccadic latency, saccadic intrusions, and square-wave jerks (SWJs) were measured for each trial. Results: As expected, UPDRS motor scores improved with both GPi and STN stimulation. With GPi stimulation, there was no significant difference in oculomotor function with stimulation on or off. However, with STN stimulation on, there was a significant increase in the mean number of SWJs/s, as well as a significant decrease in latency for both pro- and antisaccade tasks. Conclusion: Stimulation of either GPi or STN had similar effects on somatomotor function, but only STN stimulation significantly altered oculomotor function.
AB - Background: Deep brain stimulation (DBS) of either the globus pallidus interna (GPi) or subthalamic nucleus (STN) is similarly effective for treating somatomotor manifestations of Parkinson's disease (PD), but differences in how stimulation of each target affects oculomotor function are poorly understood. Objective: We sought to determine if stimulation of the STN, but not the GPi, affects oculomotor function in PD patients. Methods: Nineteen PD patients with DBS implants (8 bilateral GPi, 9 bilateral STN and 2 unilateral STN) were studied. Testing was performed with stimulation on, then off. Somatomotor function was tested using the Unified Parkinson's Disease Rating Scale (UPDRS) motor exam. For oculomotor testing, patients performed pro- and antisaccade tasks while monitored with an infrared eye tracker. Saccadic latency, saccadic intrusions, and square-wave jerks (SWJs) were measured for each trial. Results: As expected, UPDRS motor scores improved with both GPi and STN stimulation. With GPi stimulation, there was no significant difference in oculomotor function with stimulation on or off. However, with STN stimulation on, there was a significant increase in the mean number of SWJs/s, as well as a significant decrease in latency for both pro- and antisaccade tasks. Conclusion: Stimulation of either GPi or STN had similar effects on somatomotor function, but only STN stimulation significantly altered oculomotor function.
KW - Deep brain stimulation
KW - Globus pallidus
KW - Parkinson's disease
KW - Subthalamic nucleus
UR - http://www.scopus.com/inward/record.url?scp=84872771020&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872771020&partnerID=8YFLogxK
U2 - 10.1159/000343200
DO - 10.1159/000343200
M3 - Article
C2 - 23343617
AN - SCOPUS:84872771020
SN - 1011-6125
VL - 91
SP - 113
EP - 121
JO - Stereotactic and Functional Neurosurgery
JF - Stereotactic and Functional Neurosurgery
IS - 2
ER -