Effect of scatter correction on the compartmental measurement of striatal and extrastriatal dopamine D2 receptors using [ 123I]epidepride SPET

Masahiro Fujita, Andrea Varrone, Kyeong Min Kim, Hiroshi Watabe, Sami S. Zoghbi, Nicholas Seneca, Dnyanesh Tipre, John P. Seibyl, Robert B. Innis, Hidehiro Iida

Research output: Contribution to journalArticle

13 Scopus citations


Prior studies with anthropomorphic phantoms and single, static in vivo brain images have demonstrated that scatter correction significantly improves the accuracy of regional quantitation of single-photon emission tomography (SPET) brain images. Since the regional distribution of activity changes following a bolus injection of a typical neuroreceptor ligand, we examined the effect of scatter correction on the compartmental modeling of serial dynamic images of striatal and extrastriatal dopamine D2 receptors using [123I]epidepride. Eight healthy human subjects [age 30±8 (range 22-46) years] participated in a study with a bolus injection of 373±12 (354-389) MBq [123I]epidepride and data acquisition over a period of 14 h. A transmission scan was obtained in each study for attenuation and scatter correction. Distribution volumes were calculated by means of compartmental nonlinear least-squares analysis using metabolite-corrected arterial input function and brain data processed with scatter correction using narrow-beam geometry μ (SC) and without scatter correction using broad-beam μ (NoSC). Effects of SC were markedly different among brain regions. SC increased activities in the putamen and thalamus after 1-1.5 h while it decreased activity during the entire experiment in the temporal cortex and cerebellum. Compared with NoSC, SC significantly increased specific distribution volume in the putamen (58%, P=0.0001) and thalamus (23%, P=0.0297). Compared with NoSC, SC made regional distribution of the specific distribution volume closer to that of [18F]fallypride. It is concluded that SC is required for accurate quantification of distribution volumes of receptor ligands in SPET studies.

Original languageEnglish (US)
Pages (from-to)644-654
Number of pages11
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Issue number5
StatePublished - May 2004


  • Nonlinear least-squares analysis
  • Ordered subsets expectation maximization
  • Putamen
  • Temporal cortex
  • Thalamus

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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