Effect of scatter correction on the compartmental measurement of striatal and extrastriatal dopamine D2 receptors using [ 123I]epidepride SPET

Masahiro Fujita, Andrea Varrone, Kyeong Min Kim, Hiroshi Watabe, Sami S. Zoghbi, Nicholas Seneca, Dnyanesh Tipre, John P. Seibyl, Robert B. Innis, Hidehiro Iida

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Prior studies with anthropomorphic phantoms and single, static in vivo brain images have demonstrated that scatter correction significantly improves the accuracy of regional quantitation of single-photon emission tomography (SPET) brain images. Since the regional distribution of activity changes following a bolus injection of a typical neuroreceptor ligand, we examined the effect of scatter correction on the compartmental modeling of serial dynamic images of striatal and extrastriatal dopamine D2 receptors using [123I]epidepride. Eight healthy human subjects [age 30±8 (range 22-46) years] participated in a study with a bolus injection of 373±12 (354-389) MBq [123I]epidepride and data acquisition over a period of 14 h. A transmission scan was obtained in each study for attenuation and scatter correction. Distribution volumes were calculated by means of compartmental nonlinear least-squares analysis using metabolite-corrected arterial input function and brain data processed with scatter correction using narrow-beam geometry μ (SC) and without scatter correction using broad-beam μ (NoSC). Effects of SC were markedly different among brain regions. SC increased activities in the putamen and thalamus after 1-1.5 h while it decreased activity during the entire experiment in the temporal cortex and cerebellum. Compared with NoSC, SC significantly increased specific distribution volume in the putamen (58%, P=0.0001) and thalamus (23%, P=0.0297). Compared with NoSC, SC made regional distribution of the specific distribution volume closer to that of [18F]fallypride. It is concluded that SC is required for accurate quantification of distribution volumes of receptor ligands in SPET studies.

Original languageEnglish (US)
Pages (from-to)644-654
Number of pages11
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Issue number5
StatePublished - May 2004


  • Nonlinear least-squares analysis
  • Ordered subsets expectation maximization
  • Putamen
  • Temporal cortex
  • Thalamus

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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