Effect of plasmapheresis on T and B lymphocyte functions in patients with systemic lupus erythematosus: A double blind study

G. C. Tsokos, J. E. Balow, David P. Huston, N. Wei, J. L. Decker

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Nine patients with active systemic lupus erythematosus entered a double-blind randomized trial to study the therapeutic effect of vigorous versus sham reinfusion plasmapheresis. Four of them received real plasmapheresis while five received sham reinfusion plasmaphersis. In the present communication we report the effects of these procedures on T lymphocytes in peripheral mononuclear cells, proliferative responses to mitogens, allogeneic mixed lymphocyte reaction and cell-mediated lympholysis, as well as the effect of plasmapheresis on the spontaneous and pokeweed mitogen induced immunoglobulin secreting cells in peripheral blood. Several mononuclear cell functions were abnormal at the beginning of the study but no significant changes related to plasmapheresis occurred in any of the parameters studied.

Original languageEnglish (US)
Pages (from-to)449-457
Number of pages9
JournalClinical and Experimental Immunology
Volume48
Issue number2
StatePublished - Jul 13 1982

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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