Effect of pituitary adenylate cyclase activating polypeptide on rat pancreatic exocrine secretion

Zeynel Mungan, Atilla Ertan, Robert A. Hammer, Akira Arimura

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

A novel neuropeptide, pituitary adenylate cyclase activating polypeptide (PACAP), which has been isolated from ovine hypothalami, shows 68% homology with vasoactive intestinal peptide (VIP). Since VIP stimulates amylase secretion from the pancreas, we investigated the effect of PACAP and VIP on rat pancreatic exocrine secretion after intravenous injections of PACAP-27, PACAP-38, or VIP at doses of 2.5, 5 or 10 nmol/kg. Results showed: 1) Bolus injection of PACAP stimulated pancreatic amylase and protein secretions in a dose-dependent manner; and 2) Stimulation of amylase secretion with 10 nmol/kg of PACAP-27 was greater than that induced with the same dose of VIP or PACAP-38 (p<0.05).

Original languageEnglish (US)
Pages (from-to)559-562
Number of pages4
JournalPeptides
Volume12
Issue number3
DOIs
StatePublished - 1991
Externally publishedYes

Keywords

  • Amylase
  • Exocrine pancreas
  • Pituitary adenylate cyclase activating polypeptide (PACAP)
  • Rat

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Physiology
  • Endocrinology
  • Biochemistry

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