Effect of pituitary adenylate cyclase activating polypeptide on rat pancreatic exocrine secretion

Zeynel Mungan; Atilla Ertan; Robert A. Hammer; Akira Arimura

doi:10.1016/0196-9781(91)90101-T

Effect of pituitary adenylate cyclase activating polypeptide on rat pancreatic exocrine secretion

Zeynel Mungan, Atilla Ertan, Robert A. Hammer, Akira Arimura

Houston Methodist

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

A novel neuropeptide, pituitary adenylate cyclase activating polypeptide (PACAP), which has been isolated from ovine hypothalami, shows 68% homology with vasoactive intestinal peptide (VIP). Since VIP stimulates amylase secretion from the pancreas, we investigated the effect of PACAP and VIP on rat pancreatic exocrine secretion after intravenous injections of PACAP-27, PACAP-38, or VIP at doses of 2.5, 5 or 10 nmol/kg. Results showed: 1) Bolus injection of PACAP stimulated pancreatic amylase and protein secretions in a dose-dependent manner; and 2) Stimulation of amylase secretion with 10 nmol/kg of PACAP-27 was greater than that induced with the same dose of VIP or PACAP-38 (p<0.05).

Original language	English (US)
Pages (from-to)	559-562
Number of pages	4
Journal	Peptides
Volume	12
Issue number	3
DOIs	https://doi.org/10.1016/0196-9781(91)90101-T
State	Published - 1991

Keywords

Amylase
Exocrine pancreas
Pituitary adenylate cyclase activating polypeptide (PACAP)
Rat

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Physiology
Endocrinology
Biochemistry

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10.1016/0196-9781(91)90101-T

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title = "Effect of pituitary adenylate cyclase activating polypeptide on rat pancreatic exocrine secretion",

abstract = "A novel neuropeptide, pituitary adenylate cyclase activating polypeptide (PACAP), which has been isolated from ovine hypothalami, shows 68% homology with vasoactive intestinal peptide (VIP). Since VIP stimulates amylase secretion from the pancreas, we investigated the effect of PACAP and VIP on rat pancreatic exocrine secretion after intravenous injections of PACAP-27, PACAP-38, or VIP at doses of 2.5, 5 or 10 nmol/kg. Results showed: 1) Bolus injection of PACAP stimulated pancreatic amylase and protein secretions in a dose-dependent manner; and 2) Stimulation of amylase secretion with 10 nmol/kg of PACAP-27 was greater than that induced with the same dose of VIP or PACAP-38 (p<0.05).",

keywords = "Amylase, Exocrine pancreas, Pituitary adenylate cyclase activating polypeptide (PACAP), Rat",

author = "Zeynel Mungan and Atilla Ertan and Hammer, {Robert A.} and Akira Arimura",

note = "Funding Information: This study was supported by the Gastroenterology Section Research Fund 530569. The authors thank Dr. Wojciech J. Rossowski for his helpful criticism, Dr. Janet C. Rice for her help with statistical analysis, and Dr. Gillian F. Brown for editorial advice. The authors also thank Miss Lisa M. Baylor for her technical assistance. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1991",

doi = "10.1016/0196-9781(91)90101-T",

language = "English (US)",

volume = "12",

pages = "559--562",

journal = "Peptides",

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T1 - Effect of pituitary adenylate cyclase activating polypeptide on rat pancreatic exocrine secretion

AU - Mungan, Zeynel

AU - Ertan, Atilla

AU - Hammer, Robert A.

AU - Arimura, Akira

N1 - Funding Information: This study was supported by the Gastroenterology Section Research Fund 530569. The authors thank Dr. Wojciech J. Rossowski for his helpful criticism, Dr. Janet C. Rice for her help with statistical analysis, and Dr. Gillian F. Brown for editorial advice. The authors also thank Miss Lisa M. Baylor for her technical assistance. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1991

Y1 - 1991

N2 - A novel neuropeptide, pituitary adenylate cyclase activating polypeptide (PACAP), which has been isolated from ovine hypothalami, shows 68% homology with vasoactive intestinal peptide (VIP). Since VIP stimulates amylase secretion from the pancreas, we investigated the effect of PACAP and VIP on rat pancreatic exocrine secretion after intravenous injections of PACAP-27, PACAP-38, or VIP at doses of 2.5, 5 or 10 nmol/kg. Results showed: 1) Bolus injection of PACAP stimulated pancreatic amylase and protein secretions in a dose-dependent manner; and 2) Stimulation of amylase secretion with 10 nmol/kg of PACAP-27 was greater than that induced with the same dose of VIP or PACAP-38 (p<0.05).

AB - A novel neuropeptide, pituitary adenylate cyclase activating polypeptide (PACAP), which has been isolated from ovine hypothalami, shows 68% homology with vasoactive intestinal peptide (VIP). Since VIP stimulates amylase secretion from the pancreas, we investigated the effect of PACAP and VIP on rat pancreatic exocrine secretion after intravenous injections of PACAP-27, PACAP-38, or VIP at doses of 2.5, 5 or 10 nmol/kg. Results showed: 1) Bolus injection of PACAP stimulated pancreatic amylase and protein secretions in a dose-dependent manner; and 2) Stimulation of amylase secretion with 10 nmol/kg of PACAP-27 was greater than that induced with the same dose of VIP or PACAP-38 (p<0.05).

KW - Amylase

KW - Exocrine pancreas

KW - Pituitary adenylate cyclase activating polypeptide (PACAP)

KW - Rat

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AN - SCOPUS:0025909789

SN - 0196-9781

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EP - 562

JO - Peptides

JF - Peptides

IS - 3

ER -

Effect of pituitary adenylate cyclase activating polypeptide on rat pancreatic exocrine secretion

Abstract

Keywords

ASJC Scopus subject areas

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