Effect of nalorphine and naloxone on the electronocuous shock in rabbits

Eugene V. Golanov, S. B. Parin, V. V. Yasnetsov

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Electrical stimulation of the rabbit sciatic nerve resulted in the development of shock. Injection of physiological saline (1 ml, i.v.) did not change the progressive fall of blood pressure or depression of palpitation and respiration. The animals died 135-191 min after discontinuance of the stimulation. Injection of nalorphine (0.4 mg/kg, i.v.) or naloxone (0.1 mg/kg, i.v.) greatly improved the animals' condition. The blood pressure, palpitation and respiration returned to normal in 90-120 min after the injections. No lethal cases were recorded in this group of animals. It was shown in a supplementary group of animals that naloxone did not change the reserpine-produced hypotension.

Original languageEnglish (US)
Pages (from-to)60-62
Number of pages3
JournalByulleten Eksperimentalnoi Biologii i Meditsiny
Volume93
Issue number6
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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