Electrical stimulation of the rabbit sciatic nerve resulted in the development of shock. Injection of physiological saline (1 ml, i.v.) did not change the progressive fall of blood pressure or depression of palpitation and respiration. The animals died 135-191 min after discontinuance of the stimulation. Injection of nalorphine (0.4 mg/kg, i.v.) or naloxone (0.1 mg/kg, i.v.) greatly improved the animals' condition. The blood pressure, palpitation and respiration returned to normal in 90-120 min after the injections. No lethal cases were recorded in this group of animals. It was shown in a supplementary group of animals that naloxone did not change the reserpine-produced hypotension.
|Original language||English (US)|
|Number of pages||3|
|Journal||Byulleten Eksperimentalnoi Biologii i Meditsiny|
|State||Published - Jan 1 1982|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)