Effect of Haemophilus influenzae infection and moxalactam on platelet function in children

Sheldon Kaplan, J. T. Courtney, K. A.F. Kenal

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

In a prospective randomized study, children with Haemophilus influenzae type b meningitis received (i) moxalactam or (ii) ampicillin or chloramphenicol. Of 41 children, 6 had prolonged bleeding times (>6 min), and 7 of 9 tested had abnormal platelet aggregation at hospital admission. At the end of therapy, no children in the ampicillin-chloramphenicol group, compared with 5 of 22 moxalactam-treated children (23%) (P = 0.08), had prolonged bleeding times (6.5 to 7.5 min). Our data suggest that H. influenzae meningitis and treatment with moxalactam may each have an effect on platelet function in children.

Original languageEnglish (US)
Pages (from-to)467-469
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume31
Issue number3
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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