TY - JOUR
T1 - Effect of Haemophilus influenzae infection and moxalactam on platelet function in children
AU - Kaplan, Sheldon
AU - Courtney, J. T.
AU - Kenal, K. A.F.
PY - 1987
Y1 - 1987
N2 - In a prospective randomized study, children with Haemophilus influenzae type b meningitis received (i) moxalactam or (ii) ampicillin or chloramphenicol. Of 41 children, 6 had prolonged bleeding times (>6 min), and 7 of 9 tested had abnormal platelet aggregation at hospital admission. At the end of therapy, no children in the ampicillin-chloramphenicol group, compared with 5 of 22 moxalactam-treated children (23%) (P = 0.08), had prolonged bleeding times (6.5 to 7.5 min). Our data suggest that H. influenzae meningitis and treatment with moxalactam may each have an effect on platelet function in children.
AB - In a prospective randomized study, children with Haemophilus influenzae type b meningitis received (i) moxalactam or (ii) ampicillin or chloramphenicol. Of 41 children, 6 had prolonged bleeding times (>6 min), and 7 of 9 tested had abnormal platelet aggregation at hospital admission. At the end of therapy, no children in the ampicillin-chloramphenicol group, compared with 5 of 22 moxalactam-treated children (23%) (P = 0.08), had prolonged bleeding times (6.5 to 7.5 min). Our data suggest that H. influenzae meningitis and treatment with moxalactam may each have an effect on platelet function in children.
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U2 - 10.1128/AAC.31.3.467
DO - 10.1128/AAC.31.3.467
M3 - Article
C2 - 3579263
AN - SCOPUS:0023109389
VL - 31
SP - 467
EP - 469
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 3
ER -