Effect of CO2 on a brain extracellular space marker and evidence of its neuronal modulation

Thomas A. Kent; Geza Nagy; Arvin F. Oke; Sheldon H. Preskorn; Ralph N. Adams

doi:10.1016/0006-8993(85)91362-9

Effect of CO₂ on a brain extracellular space marker and evidence of its neuronal modulation

Thomas A. Kent, Geza Nagy, Arvin F. Oke, Sheldon H. Preskorn, Ralph N. Adams

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Increases in inspired CO₂ consistently altered the local concentration of the brain extracellular space marker α-naphthalene sulfonate (α-NS) as measured with ion-selective micropipettes in the rat thalamus. Stereotaxic injection of lidocaine in the region of the loccus coeruleus attenuated this effect of CO₂, and amittriptyline, a tricyclic anti-depressant and amine reuptake inhibitor, potentiated the effect. These results suggest that metabolic demand, as mimicked here by the addition of CO₂, alters the fluid environment of the brain and central noradrenergic mechanisms may modulate this response.

Original language	English (US)
Pages (from-to)	141-144
Number of pages	4
Journal	Brain Research
Volume	342
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(85)91362-9
State	Published - Sep 2 1985

Keywords

brain extracellular fluid space
ion-selective electrodes
locus coeruleus
norepinephrine

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(85)91362-9

Cite this

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title = "Effect of CO2 on a brain extracellular space marker and evidence of its neuronal modulation",

abstract = "Increases in inspired CO2 consistently altered the local concentration of the brain extracellular space marker α-naphthalene sulfonate (α-NS) as measured with ion-selective micropipettes in the rat thalamus. Stereotaxic injection of lidocaine in the region of the loccus coeruleus attenuated this effect of CO2, and amittriptyline, a tricyclic anti-depressant and amine reuptake inhibitor, potentiated the effect. These results suggest that metabolic demand, as mimicked here by the addition of CO2, alters the fluid environment of the brain and central noradrenergic mechanisms may modulate this response.",

keywords = "brain extracellular fluid space, ion-selective electrodes, locus coeruleus, norepinephrine",

author = "Kent, {Thomas A.} and Geza Nagy and Oke, {Arvin F.} and Preskorn, {Sheldon H.} and Adams, {Ralph N.}",

note = "Funding Information: The authors warmly thank Ms. Adelaide Lumary for manuscript preparation. This work was supported in part by the following grants: National Institutes of Health 5R01 NS08740 and the Center for Biomedical Research, University of Kansas (R.N.A.), Research Scientist Development Award MH-00272 and NINCDS-17252 (S.H.P.), and Pharmaceutical Manufacturers Association Foundation Fellowship Award (T.A. K ).",

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AU - Kent, Thomas A.

AU - Nagy, Geza

AU - Oke, Arvin F.

AU - Preskorn, Sheldon H.

AU - Adams, Ralph N.

N1 - Funding Information: The authors warmly thank Ms. Adelaide Lumary for manuscript preparation. This work was supported in part by the following grants: National Institutes of Health 5R01 NS08740 and the Center for Biomedical Research, University of Kansas (R.N.A.), Research Scientist Development Award MH-00272 and NINCDS-17252 (S.H.P.), and Pharmaceutical Manufacturers Association Foundation Fellowship Award (T.A. K ).

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N2 - Increases in inspired CO2 consistently altered the local concentration of the brain extracellular space marker α-naphthalene sulfonate (α-NS) as measured with ion-selective micropipettes in the rat thalamus. Stereotaxic injection of lidocaine in the region of the loccus coeruleus attenuated this effect of CO2, and amittriptyline, a tricyclic anti-depressant and amine reuptake inhibitor, potentiated the effect. These results suggest that metabolic demand, as mimicked here by the addition of CO2, alters the fluid environment of the brain and central noradrenergic mechanisms may modulate this response.

AB - Increases in inspired CO2 consistently altered the local concentration of the brain extracellular space marker α-naphthalene sulfonate (α-NS) as measured with ion-selective micropipettes in the rat thalamus. Stereotaxic injection of lidocaine in the region of the loccus coeruleus attenuated this effect of CO2, and amittriptyline, a tricyclic anti-depressant and amine reuptake inhibitor, potentiated the effect. These results suggest that metabolic demand, as mimicked here by the addition of CO2, alters the fluid environment of the brain and central noradrenergic mechanisms may modulate this response.

KW - brain extracellular fluid space

KW - ion-selective electrodes

KW - locus coeruleus

KW - norepinephrine

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