Effect of CO2 on a brain extracellular space marker and evidence of its neuronal modulation

Thomas A. Kent, Geza Nagy, Arvin F. Oke, Sheldon H. Preskorn, Ralph N. Adams

Research output: Contribution to journalArticle

6 Scopus citations


Increases in inspired CO2 consistently altered the local concentration of the brain extracellular space marker α-naphthalene sulfonate (α-NS) as measured with ion-selective micropipettes in the rat thalamus. Stereotaxic injection of lidocaine in the region of the loccus coeruleus attenuated this effect of CO2, and amittriptyline, a tricyclic anti-depressant and amine reuptake inhibitor, potentiated the effect. These results suggest that metabolic demand, as mimicked here by the addition of CO2, alters the fluid environment of the brain and central noradrenergic mechanisms may modulate this response.

Original languageEnglish (US)
Pages (from-to)141-144
Number of pages4
JournalBrain Research
Issue number1
StatePublished - Sep 2 1985


  • brain extracellular fluid space
  • ion-selective electrodes
  • locus coeruleus
  • norepinephrine

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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