Effect of cellular elements on pressure-velocity relationship in mice

A. K. Reddy, George Taffet, J. F. Prchal, L. H. Michael, M. L. Entman, C. J. Hartley

Research output: Contribution to journalConference article

Abstract

The effect of cellular elements in the blood on peripheral vascular function in mice was evaluated using the pressure-velocity relationships in the iliac arteries of 5 wild type (WT) and 3 polycythemic (MH) mice. Pressure was obtained using a fluid filled catheter in the left iliac artery and blood velocity was measured in the right iliac artery using a 20 MHz pulsed Doppler probe. The proximal aorta was then occluded for one minute to allow flow velocity to decay to zero. The pressure-velocity relationship in the diastolic phase was determined before and after aortic occlusion. In both groups the pressure-velocity relationship was almost linear and the slopes were similar. However, the extrapolated zero-velocity intercept was significantly higher for the MH than WT mice before (55.4±4.0 vs. 36.2±4.1 mmHg, p<0.01) and after occlusion (50.7±5.5 vs. 23.8±3.1 mmHg, p<0.01). Hematocrits were 41%±3 in WT and 59%±3 in MH mice. These data show that cellular elements in the blood alter the pressure-velocity relationships in peripheral vessels of mice.

Original languageEnglish (US)
Pages (from-to)3720-3722
Number of pages3
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume26 V
StatePublished - Dec 1 2004
EventConference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 - San Francisco, CA, United States
Duration: Sep 1 2004Sep 5 2004

Keywords

  • Doppler ultrasound
  • Mouse iliac artery
  • Peripheral vascular resistance
  • Polycythemia
  • Pulsatility index
  • Resistance index

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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