Abstract
The effect of 16α-cyanopregnenolone (PCN) * * Systematic names and non-standard abbreviations: PCN, 16α-cyanopregnenolone; chenodexoycholic acid, 3α, 7α-dihydroxy-5β-cholanoic acid; lithocholic acid, 3α-hydroxy-5β-cholanoic acid; deoxycholic acid, 3α, 12α-dihydroxy-5β-cholanoic acid. on the microsomal hydroxylation of tritium-labelled lithocholic acid was studied in rats. The 6β-hydroxylation increased about twice and the 7α-hydroxylation three to four times. The ability of PCN to prevent lithocholic acid-induced cholelithiasis in rats is discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 9-12 |
| Number of pages | 4 |
| Journal | Biochemical pharmacology |
| Volume | 23 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1974 |
ASJC Scopus subject areas
- Biochemistry
- Pharmacology
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