Effect of 16α-cyanopregnenolone on the hydroxylation of lithocholic acid by rat liver microsomes

Kurt Einarsson, Jan Åke Gustafsson

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The effect of 16α-cyanopregnenolone (PCN) * * Systematic names and non-standard abbreviations: PCN, 16α-cyanopregnenolone; chenodexoycholic acid, 3α, 7α-dihydroxy-5β-cholanoic acid; lithocholic acid, 3α-hydroxy-5β-cholanoic acid; deoxycholic acid, 3α, 12α-dihydroxy-5β-cholanoic acid. on the microsomal hydroxylation of tritium-labelled lithocholic acid was studied in rats. The 6β-hydroxylation increased about twice and the 7α-hydroxylation three to four times. The ability of PCN to prevent lithocholic acid-induced cholelithiasis in rats is discussed.

Original languageEnglish (US)
Pages (from-to)9-12
Number of pages4
JournalBiochemical pharmacology
Volume23
Issue number1
DOIs
StatePublished - Jan 1 1974

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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