TY - JOUR
T1 - Effect of 16α-cyanopregnenolone on the hydroxylation of lithocholic acid by rat liver microsomes
AU - Einarsson, Kurt
AU - Gustafsson, Jan Åke
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1974/1/1
Y1 - 1974/1/1
N2 - The effect of 16α-cyanopregnenolone (PCN) * * Systematic names and non-standard abbreviations: PCN, 16α-cyanopregnenolone; chenodexoycholic acid, 3α, 7α-dihydroxy-5β-cholanoic acid; lithocholic acid, 3α-hydroxy-5β-cholanoic acid; deoxycholic acid, 3α, 12α-dihydroxy-5β-cholanoic acid. on the microsomal hydroxylation of tritium-labelled lithocholic acid was studied in rats. The 6β-hydroxylation increased about twice and the 7α-hydroxylation three to four times. The ability of PCN to prevent lithocholic acid-induced cholelithiasis in rats is discussed.
AB - The effect of 16α-cyanopregnenolone (PCN) * * Systematic names and non-standard abbreviations: PCN, 16α-cyanopregnenolone; chenodexoycholic acid, 3α, 7α-dihydroxy-5β-cholanoic acid; lithocholic acid, 3α-hydroxy-5β-cholanoic acid; deoxycholic acid, 3α, 12α-dihydroxy-5β-cholanoic acid. on the microsomal hydroxylation of tritium-labelled lithocholic acid was studied in rats. The 6β-hydroxylation increased about twice and the 7α-hydroxylation three to four times. The ability of PCN to prevent lithocholic acid-induced cholelithiasis in rats is discussed.
UR - http://www.scopus.com/inward/record.url?scp=0015944816&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015944816&partnerID=8YFLogxK
U2 - 10.1016/0006-2952(74)90308-6
DO - 10.1016/0006-2952(74)90308-6
M3 - Article
C2 - 4149368
AN - SCOPUS:0015944816
SN - 0006-2952
VL - 23
SP - 9
EP - 12
JO - Biochemical pharmacology
JF - Biochemical pharmacology
IS - 1
ER -