Ectopic production of the β-subunit of human chorionic gonadotropin in osteosarcoma

N. G. Ordonez, Alberto Ayala, A. K. Raymond, C. Plager, R. S. Benjamin, N. A. Samaan

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Production of human chorionic gonadotropin by sarcomas is an uncommon phenomenon that has rarely been documented. A case of a 26-year-old woman with osteosarcoma of the left fibula and high levels of serum β-human chorionic gonadotropin (β-HCG) is described. Immunoperoxidase staining showed numerous tumor cells reacting with the β-HCG antibody. Immunohistochemical studies performed on ten additional osteosarcomas demonstrated another case in which some tumor cells presented immunoreactivity for β-HCG. These results indicate that β-HCG may be used as a marker of persistent or recurrent disease in those uncommon cases of osteosarcoma in which serum levels of β-HCG are elevated at the onset of treatment.

Original languageEnglish (US)
Pages (from-to)416-419
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Issue number4
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology


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