EBV specific CTL: A model for immune therapy

Cliona M. Rooney; H. E. Heslop; M. K. Brenner

doi:10.1111/j.1423-0410.1998.tb05463.x

EBV specific CTL: A model for immune therapy

Cliona M. Rooney, H. E. Heslop, M. K. Brenner

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33 Scopus citations

Abstract

We have been generating Epstein-Barr virus specific cytotoxic T cells for patients at high risk of developing EBV driven lymphoma. To discover the fate of the cells in vivo, we first marked them genetically, using a retroviral vector. Our results in 51 patients show that the approach is safe, that the CTL persist for several years and that they are able to mediate anti-viral and anti-tumor effects. We are now studying other virally-linked malignancies to discover whether a similar approach will be of therapeutic value.

Original language	English (US)
Pages (from-to)	497-498
Number of pages	2
Journal	Vox Sanguinis
Volume	74
Issue number	SUPPL. 2
DOIs	https://doi.org/10.1111/j.1423-0410.1998.tb05463.x
State	Published - 1998

ASJC Scopus subject areas

Hematology

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10.1111/j.1423-0410.1998.tb05463.x

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abstract = "We have been generating Epstein-Barr virus specific cytotoxic T cells for patients at high risk of developing EBV driven lymphoma. To discover the fate of the cells in vivo, we first marked them genetically, using a retroviral vector. Our results in 51 patients show that the approach is safe, that the CTL persist for several years and that they are able to mediate anti-viral and anti-tumor effects. We are now studying other virally-linked malignancies to discover whether a similar approach will be of therapeutic value.",

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T2 - A model for immune therapy

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AU - Heslop, H. E.

AU - Brenner, M. K.

PY - 1998

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AB - We have been generating Epstein-Barr virus specific cytotoxic T cells for patients at high risk of developing EBV driven lymphoma. To discover the fate of the cells in vivo, we first marked them genetically, using a retroviral vector. Our results in 51 patients show that the approach is safe, that the CTL persist for several years and that they are able to mediate anti-viral and anti-tumor effects. We are now studying other virally-linked malignancies to discover whether a similar approach will be of therapeutic value.

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ER -

EBV specific CTL: A model for immune therapy

Abstract

ASJC Scopus subject areas

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