EbpR is important for biofilm formation by activating expression of the endocarditis and biofilm-associated pilus operon (ebpABC) of Enterococcus faecalis OG1RF

Agathe Bourgogne; Kavindra V. Singh; Kristina A. Fox; Kathryn J. Pflughoeft; Barbara E. Murray; Danielle A. Garsin

doi:10.1128/JB.00594-07

EbpR is important for biofilm formation by activating expression of the endocarditis and biofilm-associated pilus operon (ebpABC) of Enterococcus faecalis OG1RF

Agathe Bourgogne, Kavindra V. Singh, Kristina A. Fox, Kathryn J. Pflughoeft, Barbara E. Murray, Danielle A. Garsin

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

We identify ef1090 (renamed ebpR) and show its importance for the transcriptional regulation of expression of the Enterococcus faecalis pilus operon, ebpABC. An ebpR deletion (ΔebpR) mutant was found to have reduced ebpABC expression with loss of pilus production and a defect in primary adherence with, as a consequence, reduced biofilm formation.

Original language	English (US)
Pages (from-to)	6490-6493
Number of pages	4
Journal	Journal of bacteriology
Volume	189
Issue number	17
DOIs	https://doi.org/10.1128/JB.00594-07
State	Published - Sep 2007

ASJC Scopus subject areas

Microbiology
Molecular Biology

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title = "EbpR is important for biofilm formation by activating expression of the endocarditis and biofilm-associated pilus operon (ebpABC) of Enterococcus faecalis OG1RF",

abstract = "We identify ef1090 (renamed ebpR) and show its importance for the transcriptional regulation of expression of the Enterococcus faecalis pilus operon, ebpABC. An ebpR deletion (ΔebpR) mutant was found to have reduced ebpABC expression with loss of pilus production and a defect in primary adherence with, as a consequence, reduced biofilm formation.",

author = "Agathe Bourgogne and Singh, {Kavindra V.} and Fox, {Kristina A.} and Pflughoeft, {Kathryn J.} and Murray, {Barbara E.} and Garsin, {Danielle A.}",

year = "2007",

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volume = "189",

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AU - Bourgogne, Agathe

AU - Singh, Kavindra V.

AU - Fox, Kristina A.

AU - Pflughoeft, Kathryn J.

AU - Murray, Barbara E.

AU - Garsin, Danielle A.

PY - 2007/9

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AB - We identify ef1090 (renamed ebpR) and show its importance for the transcriptional regulation of expression of the Enterococcus faecalis pilus operon, ebpABC. An ebpR deletion (ΔebpR) mutant was found to have reduced ebpABC expression with loss of pilus production and a defect in primary adherence with, as a consequence, reduced biofilm formation.

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IS - 17

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EbpR is important for biofilm formation by activating expression of the endocarditis and biofilm-associated pilus operon (ebpABC) of Enterococcus faecalis OG1RF

Abstract

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