EbpR is important for biofilm formation by activating expression of the endocarditis and biofilm-associated pilus operon (ebpABC) of Enterococcus faecalis OG1RF

Agathe Bourgogne, Kavindra V. Singh, Kristina A. Fox, Kathryn J. Pflughoeft, Barbara E. Murray, Danielle A. Garsin

Research output: Contribution to journalArticlepeer-review

Abstract

We identify ef1090 (renamed ebpR) and show its importance for the transcriptional regulation of expression of the Enterococcus faecalis pilus operon, ebpABC. An ebpR deletion (ΔebpR) mutant was found to have reduced ebpABC expression with loss of pilus production and a defect in primary adherence with, as a consequence, reduced biofilm formation.

Original languageEnglish (US)
Pages (from-to)6490-6493
Number of pages4
JournalJournal of bacteriology
Volume189
Issue number17
DOIs
StatePublished - Sep 2007

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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