TY - JOUR
T1 - Early Trifecta valve failure
T2 - Report of a cluster of cases from a tertiary care referral center
AU - Kalra, Ankur
AU - Rehman, Hasan
AU - Ramchandani, Mahesh
AU - Barker, Colin M.
AU - Lawrie, Gerald M.
AU - Reul, Ross M.
AU - Reardon, Michael J.
AU - Kleiman, Neal S.
N1 - Publisher Copyright:
© 2017 The American Association for Thoracic Surgery
PY - 2017/10
Y1 - 2017/10
N2 - Background The Trifecta valve (St Jude Medical, Inc, St Paul, Minn) was approved for commercial use by the US Food and Drug Administration in 2011. Several isolated cases have been reported since then, describing early structural valve deterioration. We report a case series of 8 Trifecta valve failures, describing patients’ clinical substrate and management, and the pathologic characteristics of the explanted valves. Methods Trifecta valve failure occurred in 7 patients (8 valves) receiving 19-mm (n = 2), 21-mm (n = 3), 23-mm (n = 1), and 25-mm (n = 2) valves. The mean duration of valve durability was 32 ± 21 months, and the most common lesion was prosthetic regurgitation. The mean Society of Thoracic Surgeons risk score for perioperative mortality at the time of reintervention was 9.75% ± 8.1%. Heart failure exacerbation was the most common presenting symptom. Results Five patients underwent surgical aortic valve replacement, 2 patients received valve-in-valve transcatheter aortic valve replacement, and 1 patient died of cardiogenic shock before reintervention. The most common pathologic finding in the explanted valves was a tan-yellow fibrofatty circumferential pannus adherent to the inflow portion of the Trifecta valve. Conclusions Our findings provide further insights into the pathologic mechanisms leading to early Trifecta valve failure. In addition to tear of the noncoronary cusp of the Trifecta prosthesis described as the most common mechanism in the literature for its failure, circumferential pannus formation composed of fibrofatty tissue in the inflow portion and leaflet calcification concentrated around the posts in the outflow portion are important mechanisms contributing toward early Trifecta valve failure.
AB - Background The Trifecta valve (St Jude Medical, Inc, St Paul, Minn) was approved for commercial use by the US Food and Drug Administration in 2011. Several isolated cases have been reported since then, describing early structural valve deterioration. We report a case series of 8 Trifecta valve failures, describing patients’ clinical substrate and management, and the pathologic characteristics of the explanted valves. Methods Trifecta valve failure occurred in 7 patients (8 valves) receiving 19-mm (n = 2), 21-mm (n = 3), 23-mm (n = 1), and 25-mm (n = 2) valves. The mean duration of valve durability was 32 ± 21 months, and the most common lesion was prosthetic regurgitation. The mean Society of Thoracic Surgeons risk score for perioperative mortality at the time of reintervention was 9.75% ± 8.1%. Heart failure exacerbation was the most common presenting symptom. Results Five patients underwent surgical aortic valve replacement, 2 patients received valve-in-valve transcatheter aortic valve replacement, and 1 patient died of cardiogenic shock before reintervention. The most common pathologic finding in the explanted valves was a tan-yellow fibrofatty circumferential pannus adherent to the inflow portion of the Trifecta valve. Conclusions Our findings provide further insights into the pathologic mechanisms leading to early Trifecta valve failure. In addition to tear of the noncoronary cusp of the Trifecta prosthesis described as the most common mechanism in the literature for its failure, circumferential pannus formation composed of fibrofatty tissue in the inflow portion and leaflet calcification concentrated around the posts in the outflow portion are important mechanisms contributing toward early Trifecta valve failure.
KW - aortic stenosis
KW - bioprosthetic
KW - prosthetic valve
KW - structural valve deterioration
KW - trifecta
UR - http://www.scopus.com/inward/record.url?scp=85020416148&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85020416148&partnerID=8YFLogxK
U2 - 10.1016/j.jtcvs.2017.05.044
DO - 10.1016/j.jtcvs.2017.05.044
M3 - Article
C2 - 28610762
AN - SCOPUS:85020416148
SN - 0022-5223
VL - 154
SP - 1235
EP - 1240
JO - Journal of Thoracic and Cardiovascular Surgery
JF - Journal of Thoracic and Cardiovascular Surgery
IS - 4
ER -