Early secretory antigenic target-6 of Mycobacterium tuberculosis: Enigmatic factor in pathogen-host interactions

Ramesh Chandra Rai, Ved Prakash Dwivedi, Samit Chatterjee, Durbaka Vijaya Raghava Prasad, Gobardhan Das

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

T helper (Th) 1 and 17 cells play important roles in host protective responses against tuberculosis. Early Secretory Antigenic Target 6; a Region of Difference 1 (RD1) encoded protein, mounts Th17-responses in the lung. Therefore, lack of RD-1 region makes Bacillus Calmette-Guérin (BCG) less vaccine efficacious than parent strains.

Original languageEnglish (US)
Pages (from-to)1220-1226
Number of pages7
JournalMicrobes and Infection
Volume14
Issue number13
DOIs
StatePublished - Nov 2012

Keywords

  • BCG
  • CFP10
  • ESAT6
  • Innate/adaptive immunity
  • Mycobacterium tuberculosis
  • RD-1

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

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