Early life exposure to fungal communities and allergic disease risk in children

Joanne E. Sordillo, Blake Hanson, Erica Sodergren, Michael Muilenberg, Diane R. Gold

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Research into the role of environmental fungal communities (“the mycobiome”) in allergic disease development represents an untapped domain with high potential knowledge gains, given that fungal communities are rich sources of innate immune stimuli, allergens and biologically active metabolites, the potency of which vary by taxa. In this work, we review findings from our Boston-based birth cohort study that show associations between culturable indoor fungi encountered in infancy and subsequent allergic disease risk in childhood. We present pilot ITS sequencing data and its comparison with culturable fungi, and discuss future directions, including the assessment of the “functional” products of fungal communities that may influence human health.

Original languageEnglish (US)
Title of host publication15th Conference of the International Society of Indoor Air Quality and Climate, INDOOR AIR 2018
PublisherInternational Society of Indoor Air Quality and Climate
ISBN (Electronic)9781713826514
StatePublished - 2018
Event15th Conference of the International Society of Indoor Air Quality and Climate, INDOOR AIR 2018 - Philadelphia, United States
Duration: Jul 22 2018Jul 27 2018

Publication series

Name15th Conference of the International Society of Indoor Air Quality and Climate, INDOOR AIR 2018

Conference

Conference15th Conference of the International Society of Indoor Air Quality and Climate, INDOOR AIR 2018
Country/TerritoryUnited States
CityPhiladelphia
Period7/22/187/27/18

Keywords

  • Childhood allergic disease
  • Fungi
  • Indoor microbiome
  • ITS sequencing
  • Mycobiome

ASJC Scopus subject areas

  • Pollution

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