Early improvement in cardiac function occurs for pancreas-kidney but not diabetic kidney-alone transplant recipients

A. Osama Gaber, Soliman El-Gebely, Prasanna Sugathan, Debra S. Elmer, Donna K. Hathaway, Robert B. McCully, M. Hosein Shokouh-Amiri, Brad S. Burlew

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Noninvasive M mode echocardiography with Doppler recording was prospectively performed on type I diabetic recipients of pancreas-kidney (n = 20), pancreas-after-kidney (n = 2), and kidney-alone (n = 11) allografts to determine whether the return of euglycemia by pancreas transplantation in the uremic diabetic person was associated with improved cardiac function. Each patient was studied preoperatively and at 6 and 12 months posttransplant. Echocardiographic parameters which were compared included measures of systolic function (shortening fraction), diastolic function (early/active peak velocity ratio, early/active integral ratio), and left ventricular geometric parameters (interventricular septal thickness, posterior wall thickness, left ventricular mass). The only statistically significant improvement observed for kidney-alone recipients was an increased shortening fraction from baseline (24.91%) to 6 months (32.13%, P ≤ 0.0188). In contrast, the pancreas group demonstrated sustained improvement in all outcomes with measures at 12 months consistently showing a significant improvement from baseline which was also significantly better than that reported for the kidney-alone group. This study showed stabilization of cardiac function by echocardiography for diabetic kidney-alone recipients, whereas significant improvement in function occurred for pancreas-kidney recipients. The improvement in cardiac function for pancreas recipients was seen at 6 months with continued improvement evident at 12 months.

Original languageEnglish (US)
Pages (from-to)1105-1112
Number of pages8
JournalTransplantation
Volume59
Issue number8
DOIs
StatePublished - Apr 27 1995

ASJC Scopus subject areas

  • Transplantation

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