Abstract
Epstein-Barr virus-associated lymphoproliferative disease (EBV-LPD) is a common, usually fatal, complication developing after transplantation of bone marrow from HLA-mismatched or HLA-matched unrelated donors. Prompted by recent reports of successful treatment of EBHV-LPD, we investigated methods which could result in early identification of patients at high risk for this disorder, thus improving the likelihood of successful therapeutic interventions. Both the outgrowth of transformed B lymphocytes ex vivo (100% correlation) and the detection of EBV DNA by a PCR method (80% correlation) showed statistically significant association with the histopathological diagnosis of EBV-LPD. Because these abnormalities can be detected prior to the onset of clinical disease, it should now be possible to use a combination of the methods described here to identify patients at high risk of developing EBV-LPD, thus enabling early therapeutic intervention.
Original language | English (US) |
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Pages (from-to) | 98-103 |
Number of pages | 6 |
Journal | British Journal of Haematology |
Volume | 89 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1995 |
Keywords
- BMT
- diagnosis
- Epstein-Barr virus
- lymphoproliferation
- treatment
ASJC Scopus subject areas
- Hematology