Early changes in the hypothalamic region in prodromal Huntington disease revealed by MRI analysis

The Huntington Study Group PREDICT-HD investigators

Research output: Contribution to journalArticlepeer-review

71 Scopus citations


Huntington disease (HD) is a fatal neurodegenerative disorder caused by an expanded CAG repeat. Its length can be used to estimate the time of clinical diagnosis, which is defined by overt motor symptoms. Non-motor symptoms begin before motor onset, and involve changes in hypothalamus-regulated functions such as sleep, emotion and metabolism. Therefore we hypothesized that hypothalamic changes occur already prior to the clinical diagnosis. We performed voxel-based morphometry and logistic regression analyses of cross-sectional MR images from 220 HD gene carriers and 75 controls in the Predict-HD study. We show that changes in the hypothalamic region are detectable before clinical diagnosis and that its grey matter contents alone are sufficient to distinguish HD gene carriers from control cases. In conclusion, our study shows, for the first time, that alterations in grey matter contents in the hypothalamic region occur at least a decade before clinical diagnosis in HD using MRI.

Original languageEnglish (US)
Pages (from-to)531-543
Number of pages13
JournalNeurobiology of Disease
Issue number3
StatePublished - Oct 1 2010


  • Atrophy
  • Basal ganglia
  • Huntingtin
  • Hypothalamus
  • Imaging
  • Neuroendocrine

ASJC Scopus subject areas

  • Neurology


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