E-selectin-targeted porous silicon particle for nanoparticle delivery to the bone marrow

Aman P. Mann, Takemi Tanaka, Anoma Somasunderam, Xuewu Liu, David G. Gorenstein, Mauro Ferrari

Research output: Contribution to journalArticle

95 Scopus citations

Abstract

A multifunctional drug delivery system is developed comprising biodegradable porous silicon microparticles that act as motherships to ferry different types of imaging and therapeutic nanoparticles loaded within their porous structure. An E-selectin thioaptamer ligand is used to actively target this delivery system to the bone marrow vasculature where the payload is released as the porous silicon underwent degradation under physiological conditions.

Original languageEnglish (US)
Pages (from-to)H278-H282
JournalAdvanced Materials
Volume23
Issue number36
DOIs
StatePublished - Sep 22 2011

Keywords

  • bone marrow
  • E-selectin
  • nanomedicine
  • porous silicon
  • thioaptamers

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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