E-selectin-targeted porous silicon particle for nanoparticle delivery to the bone marrow

Aman P. Mann; Takemi Tanaka; Anoma Somasunderam; Xuewu Liu; David G. Gorenstein; Mauro Ferrari

doi:10.1002/adma.201101541

E-selectin-targeted porous silicon particle for nanoparticle delivery to the bone marrow

Aman P. Mann, Takemi Tanaka, Anoma Somasunderam, Xuewu Liu, David G. Gorenstein, Mauro Ferrari

Research output: Contribution to journal › Article › peer-review

114 Scopus citations

Abstract

A multifunctional drug delivery system is developed comprising biodegradable porous silicon microparticles that act as motherships to ferry different types of imaging and therapeutic nanoparticles loaded within their porous structure. An E-selectin thioaptamer ligand is used to actively target this delivery system to the bone marrow vasculature where the payload is released as the porous silicon underwent degradation under physiological conditions.

Original language	English (US)
Pages (from-to)	H278-H282
Journal	Advanced Materials
Volume	23
Issue number	36
DOIs	https://doi.org/10.1002/adma.201101541
State	Published - Sep 22 2011

Keywords

bone marrow
E-selectin
nanomedicine
porous silicon
thioaptamers

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.201101541

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AU - Somasunderam, Anoma

AU - Liu, Xuewu

AU - Gorenstein, David G.

AU - Ferrari, Mauro

PY - 2011/9/22

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AB - A multifunctional drug delivery system is developed comprising biodegradable porous silicon microparticles that act as motherships to ferry different types of imaging and therapeutic nanoparticles loaded within their porous structure. An E-selectin thioaptamer ligand is used to actively target this delivery system to the bone marrow vasculature where the payload is released as the porous silicon underwent degradation under physiological conditions.

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KW - nanomedicine

KW - porous silicon

KW - thioaptamers

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E-selectin-targeted porous silicon particle for nanoparticle delivery to the bone marrow

Abstract

Keywords

ASJC Scopus subject areas

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