Dysregulation of oxygen hemodynamic responses to synaptic train stimulation in a rat hippocampal model of subarachnoid hemorrhage

Francesca Galeffi, Simone Degan, Gavin Britz, Dennis A. Turner

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

We investigated microvascular reactivity to synaptic train stimulation after induction of subarachnoid hemorrhage in adult rats, analyzing tissue oxygen levels [pO2 ] in intact hippocampus. In control rats, hippocampal pO2 averaged 11.4 mm Hg whereas hemodynamic responses averaged 13.1 mm Hg (to a 25 s train). After subarachnoid hemorrhage (at 2 days), we recorded a dramatic elevation in baseline pO2 in the hippocampus (to 68.4 mm Hg) accompanied by inverted pO2 responses to synaptic train stimulation (-9.46 mm Hg). These significant changes in baseline hippocampal pO2 and inverted pO2 responses after subarachnoid hemorrhage indicate severe alterations of neurovascular coupling and neuronal viability.

Original languageEnglish (US)
Pages (from-to)696-701
Number of pages6
JournalJournal of Cerebral Blood Flow and Metabolism
Volume36
Issue number4
DOIs
StatePublished - 2015

Keywords

  • Hippocampus
  • hemodynamics
  • hyperemia
  • neurovascular coupling
  • optical imaging
  • physiological stimulation
  • subarachnoid hemorrhage
  • tissue oxygen
  • vasospasm

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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