Abstract
We investigated microvascular reactivity to synaptic train stimulation after induction of subarachnoid hemorrhage in adult rats, analyzing tissue oxygen levels [pO2 ] in intact hippocampus. In control rats, hippocampal pO2 averaged 11.4 mm Hg whereas hemodynamic responses averaged 13.1 mm Hg (to a 25 s train). After subarachnoid hemorrhage (at 2 days), we recorded a dramatic elevation in baseline pO2 in the hippocampus (to 68.4 mm Hg) accompanied by inverted pO2 responses to synaptic train stimulation (-9.46 mm Hg). These significant changes in baseline hippocampal pO2 and inverted pO2 responses after subarachnoid hemorrhage indicate severe alterations of neurovascular coupling and neuronal viability.
Original language | English (US) |
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Pages (from-to) | 696-701 |
Number of pages | 6 |
Journal | Journal of Cerebral Blood Flow and Metabolism |
Volume | 36 |
Issue number | 4 |
DOIs | |
State | Published - 2015 |
Keywords
- Hippocampus
- hemodynamics
- hyperemia
- neurovascular coupling
- optical imaging
- physiological stimulation
- subarachnoid hemorrhage
- tissue oxygen
- vasospasm
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
- Cardiology and Cardiovascular Medicine