Dyslipidemia and the vulnerable plaque

John A. Farmer, Antonio Gotto

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


In the last decade, an increasingly sophisticated understanding of the pathogenesis of atherosclerosis and its cardiovascular consequences has emerged. The characteristics of the unstable atherosclerotic plaque, the substrate for the majority of acute coronary events, have been well defined: mild-to-moderate stenosis, a lipid-rich pool, few smooth muscle cells, a friable fibrous cap, and macrophage infiltration. Lipid modification, an important cardiovascular risk reduction strategy, induces a number of effects at the vascular level that may contribute to the clinical benefits seen in large-scale, prospective prevention trials. New developments in imaging technologies may afford improved opportunities to visualize the atrisk plaque and may provide new insights into the optimal management of the unstable plaque.

Original languageEnglish (US)
Pages (from-to)415-428
Number of pages14
JournalProgress in Cardiovascular Diseases
Issue number6
StatePublished - Jan 1 2002

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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