Dynamic model of biomolecular diffusion through two-dimensional nanochannels

Carlo Cosentino, Francesco Amato, Robbie Walczak, Anthony Boiarski, Mauro Ferrari

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

The molecular diffusion dynamics in unconstrained cases has been studied thoroughly during the last two centuries, leading to the well-known Fick's diffusion laws and Stokes-Einstein equation. More recently, a new impulse to the study of this topic has been provided by the necessity of understanding the behavior of solute particles in the presence of environmental constraints of size comparable to the molecular dimensions. In this work, we investigate the diffusion kinetics of biomolecules, such as bovine scrum albumin, interferon, and lysozyme, through microfabricated silicon membranes, having pores of nanometric size in only one dimension, in the range from few to tens of nanometers (the other dimensions are in the μm range). Experimental results show that the diffusion profiles, in some cases, deviate substantially from those predicted by Fick's laws. In light of these results, a new diffusion mathematical model is proposed, which can reasonably explain the phenomenon and, at the same time, recovers the classical diffusion laws in the unconstrained case. Moreover, a physical description, derived from van der Waals equation of state, is presented, and it is compared with the results obtained by the mathematical model.

Original languageEnglish (US)
Pages (from-to)7358-7364
Number of pages7
JournalJournal of Physical Chemistry B
Volume109
Issue number15
DOIs
StatePublished - Apr 21 2005

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Dynamic model of biomolecular diffusion through two-dimensional nanochannels'. Together they form a unique fingerprint.

Cite this