Dynamic coagulation studies: Influence of normal and abnormal platelets on clot structure formation

C. J. Glover, L. V. McIntire, C. H. Brown, E. A. Natelson

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The interaction of platelets with polymerizing fibrin was studied in recalcified plasma systems, utilizing rheological and biochemical techniques. The effect of platelet concentration on the viscoelastic properties (storage and loss moduli) of clots during clot structure formation was ascertained. Maximum storage modulus (a measure of clot strength) increased more than one order of magnitude when platelet-rich plasma rather than platelet-free plasma was clotted and a quantitative relationship between maximum storage modulus and platelet concentration was obtained. Results suggested that clot retraction was a major determinant of clot strength. Studies of samples with abnormal platelet function strongly supported this view, since defective platelet aggregation to ADP, collagen and epinephrine did not affect final clot strength unless accompanied by markedly abnormal clot retraction. It is proposed that rheological studies are useful in examining the interaction of platelets with fibrin and that alterations in such an interaction may be responsible for hemostatic defects associated with quantitative or qualitative platelet disorders.

Original languageEnglish (US)
Pages (from-to)185-198
Number of pages14
JournalThrombosis Research
Volume7
Issue number1
DOIs
StatePublished - Jan 1 1975

ASJC Scopus subject areas

  • Hematology

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