Dual responsive, stabilized nanoparticles for efficient in vivo plasmid delivery

Hua Wei; Lisa R. Volpatti; Drew L. Sellers; Don O. Maris; Ian W. Andrews; Ashton S. Hemphill; Leslie W. Chan; David S H Chu; Philip J. Horner; Suzie H. Pun

doi:10.1002/anie.201301896

Dual responsive, stabilized nanoparticles for efficient in vivo plasmid delivery

Hua Wei, Lisa R. Volpatti, Drew L. Sellers, Don O. Maris, Ian W. Andrews, Ashton S. Hemphill, Leslie W. Chan, David S H Chu, Philip J. Horner, Suzie H. Pun

Center for Neuroregeneration

Research output: Contribution to journal › Article › peer-review

117 Scopus citations

Abstract

A small case of love and hate: A block-statistical copolymer combining reversible hydrophobization and statistical hydrophilization allows the preparation of pH value- and reduction-responsive nanoparticles (polyplexes) for efficient in vivo plasmid delivery.

Original language	English (US)
Pages (from-to)	5377-5381
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	20
DOIs	https://doi.org/10.1002/anie.201301896
State	Published - May 10 2013

Keywords

DNA nanoparticles
copolymers
gene transfection
hydrophilization
hydrophobization

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.201301896

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title = "Dual responsive, stabilized nanoparticles for efficient in vivo plasmid delivery",

abstract = "A small case of love and hate: A block-statistical copolymer combining reversible hydrophobization and statistical hydrophilization allows the preparation of pH value- and reduction-responsive nanoparticles (polyplexes) for efficient in vivo plasmid delivery.",

keywords = "DNA nanoparticles, copolymers, gene transfection, hydrophilization, hydrophobization",

author = "Hua Wei and Volpatti, \{Lisa R.\} and Sellers, \{Drew L.\} and Maris, \{Don O.\} and Andrews, \{Ian W.\} and Hemphill, \{Ashton S.\} and Chan, \{Leslie W.\} and Chu, \{David S H\} and Horner, \{Philip J.\} and Pun, \{Suzie H.\}",

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T1 - Dual responsive, stabilized nanoparticles for efficient in vivo plasmid delivery

AU - Wei, Hua

AU - Volpatti, Lisa R.

AU - Sellers, Drew L.

AU - Maris, Don O.

AU - Andrews, Ian W.

AU - Hemphill, Ashton S.

AU - Chan, Leslie W.

AU - Chu, David S H

AU - Horner, Philip J.

AU - Pun, Suzie H.

PY - 2013/5/10

Y1 - 2013/5/10

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KW - DNA nanoparticles

KW - copolymers

KW - gene transfection

KW - hydrophilization

KW - hydrophobization

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ER -

Dual responsive, stabilized nanoparticles for efficient in vivo plasmid delivery

Abstract

Keywords

ASJC Scopus subject areas

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