Dual responsive, stabilized nanoparticles for efficient in vivo plasmid delivery

Hua Wei, Lisa R. Volpatti, Drew L. Sellers, Don O. Maris, Ian W. Andrews, Ashton S. Hemphill, Leslie W. Chan, David S H Chu, Philip J. Horner, Suzie H. Pun

Research output: Contribution to journalArticle

96 Scopus citations

Abstract

A small case of love and hate: A block-statistical copolymer combining reversible hydrophobization and statistical hydrophilization allows the preparation of pH value- and reduction-responsive nanoparticles (polyplexes) for efficient in vivo plasmid delivery.

Original languageEnglish (US)
Pages (from-to)5377-5381
Number of pages5
JournalAngewandte Chemie - International Edition
Volume52
Issue number20
DOIs
StatePublished - May 10 2013

Keywords

  • DNA nanoparticles
  • copolymers
  • gene transfection
  • hydrophilization
  • hydrophobization

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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