Dual resistance to adamantanes and oseltamivir among seasonal influenza A(H1N1) viruses: 2008-2010

Tiffany G. Sheu; Alicia M. Fry; Rebecca J. Garten; Varough M. Deyde; Thein Shwe; Lesley Bullion; Patrick J. Peebles; Yan Li; Alexander I. Klimov; Larisa V. Gubareva

doi:10.1093/infdis/jiq005

Dual resistance to adamantanes and oseltamivir among seasonal influenza A(H1N1) viruses: 2008-2010

Tiffany G. Sheu, Alicia M. Fry, Rebecca J. Garten, Varough M. Deyde, Thein Shwe, Lesley Bullion, Patrick J. Peebles, Yan Li, Alexander I. Klimov, Larisa V. Gubareva

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120 Scopus citations

Abstract

Two distinct genetic clades of seasonal influenza A(H1N1) viruses have cocirculated in the recent seasons: clade 2B oseltamivir-resistant and adamantane-susceptible viruses, and clade 2C viruses that are resistant to adamantanes and susceptible to oseltamivir. We tested seasonal influenza A(H1N1) viruses collected in 2008-2010 from the United States and globally for resistance to antivirals approved by the Food and Drug Administration. We report 28 viruses with both adamantane and oseltamivir (dual) resistance from 5 countries belonging to 4 distinct genotypes. Because of limited options for antiviral treatment, emergence of dual-resistant influenza viruses poses a public health concern, and their circulation needs to be closely monitored.

Original language	English (US)
Pages (from-to)	13-17
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	203
Issue number	1
DOIs	https://doi.org/10.1093/infdis/jiq005
State	Published - Jan 1 2011

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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title = "Dual resistance to adamantanes and oseltamivir among seasonal influenza A(H1N1) viruses: 2008-2010",

abstract = "Two distinct genetic clades of seasonal influenza A(H1N1) viruses have cocirculated in the recent seasons: clade 2B oseltamivir-resistant and adamantane-susceptible viruses, and clade 2C viruses that are resistant to adamantanes and susceptible to oseltamivir. We tested seasonal influenza A(H1N1) viruses collected in 2008-2010 from the United States and globally for resistance to antivirals approved by the Food and Drug Administration. We report 28 viruses with both adamantane and oseltamivir (dual) resistance from 5 countries belonging to 4 distinct genotypes. Because of limited options for antiviral treatment, emergence of dual-resistant influenza viruses poses a public health concern, and their circulation needs to be closely monitored.",

author = "Sheu, {Tiffany G.} and Fry, {Alicia M.} and Garten, {Rebecca J.} and Deyde, {Varough M.} and Thein Shwe and Lesley Bullion and Peebles, {Patrick J.} and Yan Li and Klimov, {Alexander I.} and Gubareva, {Larisa V.}",

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AU - Fry, Alicia M.

AU - Garten, Rebecca J.

AU - Deyde, Varough M.

AU - Shwe, Thein

AU - Bullion, Lesley

AU - Peebles, Patrick J.

AU - Li, Yan

AU - Klimov, Alexander I.

AU - Gubareva, Larisa V.

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AB - Two distinct genetic clades of seasonal influenza A(H1N1) viruses have cocirculated in the recent seasons: clade 2B oseltamivir-resistant and adamantane-susceptible viruses, and clade 2C viruses that are resistant to adamantanes and susceptible to oseltamivir. We tested seasonal influenza A(H1N1) viruses collected in 2008-2010 from the United States and globally for resistance to antivirals approved by the Food and Drug Administration. We report 28 viruses with both adamantane and oseltamivir (dual) resistance from 5 countries belonging to 4 distinct genotypes. Because of limited options for antiviral treatment, emergence of dual-resistant influenza viruses poses a public health concern, and their circulation needs to be closely monitored.

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Dual resistance to adamantanes and oseltamivir among seasonal influenza A(H1N1) viruses: 2008-2010

Abstract

ASJC Scopus subject areas

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