Dual-Mode IVUS Transducer for Image-Guided Brain Therapy: Preliminary Experiments

Carl D. Herickhoff; Christy M. Wilson; Gerald A. Grant; Gavin W. Britz; Edward D. Light; Mark L. Palmeri; Patrick D. Wolf; Stephen W. Smith

doi:10.1016/j.ultrasmedbio.2011.06.017

Dual-Mode IVUS Transducer for Image-Guided Brain Therapy: Preliminary Experiments

Carl D. Herickhoff, Christy M. Wilson, Gerald A. Grant, Gavin W. Britz, Edward D. Light, Mark L. Palmeri, Patrick D. Wolf, Stephen W. Smith

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

In this study, we investigated the feasibility of using 3.5-Fr intravascular ultrasound (IVUS) catheters for minimally-invasive, image-guided hyperthermia treatment of tumors in the brain. Feasibility was demonstrated by: (1) retro-fitting a commercial 3.5-Fr IVUS catheter with a 5 × 0.5 × 0.22 mm PZT-4 transducer for 9-MHz imaging and (2) testing an identical transducer for therapy potential with 3.3-MHz continuous-wave excitation. The imaging transducer was compared with a 9-Fr, 9-MHz ICE catheter when visualizing the post-mortem ovine brain and was also used to attempt vascular access to an in vivo porcine brain. A net average electrical power input of 700 mW was applied to the therapy transducer, producing a temperature rise of +13.5°C at a depth of 1.5 mm in live brain tumor tissue in the mouse model. These results suggest that it may be feasible to combine the imaging and therapeutic capabilities into a single device as a clinically-viable instrument.

Original language	English (US)
Pages (from-to)	1667-1676
Number of pages	10
Journal	Ultrasound in Medicine and Biology
Volume	37
Issue number	10
DOIs	https://doi.org/10.1016/j.ultrasmedbio.2011.06.017
State	Published - Oct 2011

Keywords

Dual-mode catheter transducer
Intravascular ultrasound
Ultrasound hyperthermia

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Radiological and Ultrasound Technology
Biophysics

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10.1016/j.ultrasmedbio.2011.06.017

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title = "Dual-Mode IVUS Transducer for Image-Guided Brain Therapy: Preliminary Experiments",

abstract = "In this study, we investigated the feasibility of using 3.5-Fr intravascular ultrasound (IVUS) catheters for minimally-invasive, image-guided hyperthermia treatment of tumors in the brain. Feasibility was demonstrated by: (1) retro-fitting a commercial 3.5-Fr IVUS catheter with a 5 × 0.5 × 0.22 mm PZT-4 transducer for 9-MHz imaging and (2) testing an identical transducer for therapy potential with 3.3-MHz continuous-wave excitation. The imaging transducer was compared with a 9-Fr, 9-MHz ICE catheter when visualizing the post-mortem ovine brain and was also used to attempt vascular access to an in vivo porcine brain. A net average electrical power input of 700 mW was applied to the therapy transducer, producing a temperature rise of +13.5°C at a depth of 1.5 mm in live brain tumor tissue in the mouse model. These results suggest that it may be feasible to combine the imaging and therapeutic capabilities into a single device as a clinically-viable instrument.",

keywords = "Dual-mode catheter transducer, Intravascular ultrasound, Ultrasound hyperthermia",

author = "Herickhoff, {Carl D.} and Wilson, {Christy M.} and Grant, {Gerald A.} and Britz, {Gavin W.} and Light, {Edward D.} and Palmeri, {Mark L.} and Wolf, {Patrick D.} and Smith, {Stephen W.}",

note = "Funding Information: The authors thank Volcano Corporation for their support in this study, as well as Veronica Rotemberg, Samantha Lipman, Josh Doherty, Tat-Jin Teo, Rick Stouffer and Ellen Dixon-Tulloch for their assistance. This work was supported by NIH grant HL089507 . ",

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AU - Britz, Gavin W.

AU - Light, Edward D.

AU - Palmeri, Mark L.

AU - Wolf, Patrick D.

AU - Smith, Stephen W.

N1 - Funding Information: The authors thank Volcano Corporation for their support in this study, as well as Veronica Rotemberg, Samantha Lipman, Josh Doherty, Tat-Jin Teo, Rick Stouffer and Ellen Dixon-Tulloch for their assistance. This work was supported by NIH grant HL089507 .

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Dual-Mode IVUS Transducer for Image-Guided Brain Therapy: Preliminary Experiments

Abstract

Keywords

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