Dual-Mode IVUS Transducer for Image-Guided Brain Therapy: Preliminary Experiments

Carl D. Herickhoff, Christy M. Wilson, Gerald A. Grant, Gavin W. Britz, Edward D. Light, Mark L. Palmeri, Patrick D. Wolf, Stephen W. Smith

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

In this study, we investigated the feasibility of using 3.5-Fr intravascular ultrasound (IVUS) catheters for minimally-invasive, image-guided hyperthermia treatment of tumors in the brain. Feasibility was demonstrated by: (1) retro-fitting a commercial 3.5-Fr IVUS catheter with a 5 × 0.5 × 0.22 mm PZT-4 transducer for 9-MHz imaging and (2) testing an identical transducer for therapy potential with 3.3-MHz continuous-wave excitation. The imaging transducer was compared with a 9-Fr, 9-MHz ICE catheter when visualizing the post-mortem ovine brain and was also used to attempt vascular access to an in vivo porcine brain. A net average electrical power input of 700 mW was applied to the therapy transducer, producing a temperature rise of +13.5°C at a depth of 1.5 mm in live brain tumor tissue in the mouse model. These results suggest that it may be feasible to combine the imaging and therapeutic capabilities into a single device as a clinically-viable instrument.

Original languageEnglish (US)
Pages (from-to)1667-1676
Number of pages10
JournalUltrasound in Medicine and Biology
Volume37
Issue number10
DOIs
StatePublished - Oct 2011

Keywords

  • Dual-mode catheter transducer
  • Intravascular ultrasound
  • Ultrasound hyperthermia

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Biophysics

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