Dual-mode intracranial catheters for minimally-invasive neuro-oncology feasibility study

Carl D. Herickhoff, Edward D. Light, Patrick D. Wolf, Stephen W. Smith, Gerald A. Grant, Gavin W. Britz

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

In this study, we investigated the feasibility of dual-mode intracranial catheter transducers for visualization and treatment of tumors in the brain. Feasibility is demonstrated in two ways: 1) by developing a 12 Fr, integrated matrix and linear array catheter transducer prototype for combined real-time 3D imaging and heating, and 2) by testing 3.5 Fr IVUS-catheter-packageable transducers for therapeutic potential. The 3.6 MHz, 12 Fr catheter acquired real-time 3D images of canine brain structures in vivo while placed in the superior sagittal sinus via a burr hole in the skull, and achieved a 3.5°C temperature rise in tissue-mimicking material at a 2 cm focus in vitro. The IVUS-sized prototype transducers were tested for maximum intensity and mechanical index, and a thermal model was used to extrapolate and estimate each transducer's maximum potential temperature rise in brain tissue.

Original languageEnglish (US)
Title of host publication2009 IEEE International Ultrasonics Symposium and Short Courses, IUS 2009
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1012-1015
Number of pages4
ISBN (Print)9781424443895
DOIs
StatePublished - 2009
Event2009 IEEE International Ultrasonics Symposium, IUS 2009 - Rome, Italy
Duration: Sep 20 2009Sep 23 2009

Publication series

NameProceedings - IEEE Ultrasonics Symposium
ISSN (Print)1051-0117

Other

Other2009 IEEE International Ultrasonics Symposium, IUS 2009
CountryItaly
CityRome
Period9/20/099/23/09

Keywords

  • Dual-mode catheter transducer
  • Intravascular ultrasound
  • Ultrasound hyperthermia

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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