Drug Insight: The role of statins in combination with ezetimibe to lower LDL cholesterol

Antonio Gotto, John A. Farmer

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


The cardiovascular benefits of therapy with the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are well documented. Undertreatment of dyslipidemia remains pervasive, however, and the introduction of more-aggressive optional LDL-cholesterol targets in US guidelines only heightens the challenges of reaching the target values. Combination therapy with a statin and the cholesterol absorption inhibitor ezetimibe could help in the management of patients who have an inadequate reduction in cholesterol after making changes to lifestyle or taking statins alone. The effects of the combination on cardiovascular risk remain speculative, however, and clinical trials are in development. In this Review we consider the rationale for combination therapy in the context of achieving LDL-cholesterol goals.

Original languageEnglish (US)
Pages (from-to)664-672
Number of pages9
JournalNature Clinical Practice Cardiovascular Medicine
Issue number12
StatePublished - Dec 1 2006

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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