TY - JOUR
T1 - Drug-induced skin reactions
T2 - A 2-year study
AU - Farshchian, Mahmood
AU - Ansar, Akram
AU - Zamanian, Abbas
AU - Rahmatpour-Rokni, Ghasem
AU - Kimyai-Asadi, Arash
AU - Farshchian, Mehdi
PY - 2015/2/10
Y1 - 2015/2/10
N2 - Background: The aim of this study was to analyze the clinical characteristics of patients with adverse cutaneous drug reactions, which occur when a medicinal product results in cutaneous morbidity. Methods: The study included 308 patients who were diagnosed as having an adverse cutaneous drug reaction during the study period (2007–2009). In 84 cases, histopathologic examination of skin biopsies were also performed. Results: Patients with drug reactions were found to be more commonly female (63%) than male (37%). Beta-lactam antibiotics were found to be the most frequent cause of adverse cutaneous drug reactions (42.7%), followed by non-steroidal anti-infammatory drugs (16.5%). Acute urticaria was the most common clinical presentation (59.2%) followed by fxed drug eruptions (18.5%), and maculopapular eruptions (14.9%). Conclusion: Adverse cutaneous drug reactions in our study population were mainly induced by beta-lactam antibiotics and non-steroidal anti-inflammatory drugs. The most common forms of cutaneous adverse drug reactions were found to be acute urticaria, fxed drug eruptions, and maculopapular rashes.
AB - Background: The aim of this study was to analyze the clinical characteristics of patients with adverse cutaneous drug reactions, which occur when a medicinal product results in cutaneous morbidity. Methods: The study included 308 patients who were diagnosed as having an adverse cutaneous drug reaction during the study period (2007–2009). In 84 cases, histopathologic examination of skin biopsies were also performed. Results: Patients with drug reactions were found to be more commonly female (63%) than male (37%). Beta-lactam antibiotics were found to be the most frequent cause of adverse cutaneous drug reactions (42.7%), followed by non-steroidal anti-infammatory drugs (16.5%). Acute urticaria was the most common clinical presentation (59.2%) followed by fxed drug eruptions (18.5%), and maculopapular eruptions (14.9%). Conclusion: Adverse cutaneous drug reactions in our study population were mainly induced by beta-lactam antibiotics and non-steroidal anti-inflammatory drugs. The most common forms of cutaneous adverse drug reactions were found to be acute urticaria, fxed drug eruptions, and maculopapular rashes.
KW - Acute urticaria
KW - Adverse drug reaction
KW - Exanthematous eruption
UR - http://www.scopus.com/inward/record.url?scp=84922592739&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922592739&partnerID=8YFLogxK
U2 - 10.2147/CCID.S75849
DO - 10.2147/CCID.S75849
M3 - Article
AN - SCOPUS:84922592739
VL - 8
SP - 53
EP - 56
JO - Clinical, Cosmetic and Investigational Dermatology
JF - Clinical, Cosmetic and Investigational Dermatology
SN - 1178-7015
ER -