Drug-Eluting Stent, Drug-Coated Balloon, or Plain Old Balloon Angioplasty for In-Stent Coronary Restenosis: Insights From a Mixed Treatment Comparison Meta-Analysis of Randomized Trials

M. Haisum Maqsood; Robert S. Zhang; Nil Rawal; Gal Sella; Neal S. Kleiman; Sripal Bangalore

doi:10.1161/CIRCINTERVENTIONS.125.015161

Drug-Eluting Stent, Drug-Coated Balloon, or Plain Old Balloon Angioplasty for In-Stent Coronary Restenosis: Insights From a Mixed Treatment Comparison Meta-Analysis of Randomized Trials

M. Haisum Maqsood, Robert S. Zhang, Nil Rawal, Gal Sella, Neal S. Kleiman, Sripal Bangalore

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: – Drug-coated balloons (DCBs) are now a Food and Drug Administration-approved treatment option for the management of in-stent restenosis (ISR) based on superior outcomes compared with plain old balloon angioplasty (POBA) alone. However, the efficacy of DCB compared with drug-eluting stent (DES; repeat stenting) for ISR is uncertain, with prior studies showing inferiority of DCB. We aimed to compare the outcomes of DES, DCB, or POBA in patients with coronary ISR. METHODS: – We searched PubMed, EMBASE, and https://www.crd.york.ac.uk/PROSPERO; Unique identifier: CRD42024598433.

Original language	English (US)
Pages (from-to)	e015161
Journal	Circulation: Cardiovascular Interventions
Volume	18
Issue number	12
DOIs	https://doi.org/10.1161/CIRCINTERVENTIONS.125.015161
State	Published - Dec 2025

Keywords

coronary artery disease
drug-eluting stents
percutaneous coronary intervention

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Access to Document

10.1161/CIRCINTERVENTIONS.125.015161

Cite this

Maqsood, M. H., Zhang, R. S., Rawal, N., Sella, G., Kleiman, N. S., & Bangalore, S. (2025). Drug-Eluting Stent, Drug-Coated Balloon, or Plain Old Balloon Angioplasty for In-Stent Coronary Restenosis: Insights From a Mixed Treatment Comparison Meta-Analysis of Randomized Trials. Circulation: Cardiovascular Interventions, 18(12), e015161. https://doi.org/10.1161/CIRCINTERVENTIONS.125.015161

Drug-Eluting Stent, Drug-Coated Balloon, or Plain Old Balloon Angioplasty for In-Stent Coronary Restenosis: Insights From a Mixed Treatment Comparison Meta-Analysis of Randomized Trials. / Maqsood, M. Haisum; Zhang, Robert S.; Rawal, Nil et al.
In: Circulation: Cardiovascular Interventions, Vol. 18, No. 12, 12.2025, p. e015161.

Research output: Contribution to journal › Article › peer-review

Maqsood, MH, Zhang, RS, Rawal, N, Sella, G, Kleiman, NS & Bangalore, S 2025, 'Drug-Eluting Stent, Drug-Coated Balloon, or Plain Old Balloon Angioplasty for In-Stent Coronary Restenosis: Insights From a Mixed Treatment Comparison Meta-Analysis of Randomized Trials', Circulation: Cardiovascular Interventions, vol. 18, no. 12, pp. e015161. https://doi.org/10.1161/CIRCINTERVENTIONS.125.015161

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abstract = "BACKGROUND: – Drug-coated balloons (DCBs) are now a Food and Drug Administration-approved treatment option for the management of in-stent restenosis (ISR) based on superior outcomes compared with plain old balloon angioplasty (POBA) alone. However, the efficacy of DCB compared with drug-eluting stent (DES; repeat stenting) for ISR is uncertain, with prior studies showing inferiority of DCB. We aimed to compare the outcomes of DES, DCB, or POBA in patients with coronary ISR. METHODS: – We searched PubMed, EMBASE, and https://www.crd.york.ac.uk/PROSPERO; Unique identifier: CRD42024598433.",

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AB - BACKGROUND: – Drug-coated balloons (DCBs) are now a Food and Drug Administration-approved treatment option for the management of in-stent restenosis (ISR) based on superior outcomes compared with plain old balloon angioplasty (POBA) alone. However, the efficacy of DCB compared with drug-eluting stent (DES; repeat stenting) for ISR is uncertain, with prior studies showing inferiority of DCB. We aimed to compare the outcomes of DES, DCB, or POBA in patients with coronary ISR. METHODS: – We searched PubMed, EMBASE, and https://www.crd.york.ac.uk/PROSPERO; Unique identifier: CRD42024598433.

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Drug-Eluting Stent, Drug-Coated Balloon, or Plain Old Balloon Angioplasty for In-Stent Coronary Restenosis: Insights From a Mixed Treatment Comparison Meta-Analysis of Randomized Trials

Abstract

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