Drug Delivery in an Orthotopic Tumor Stem Cell-Based Model of Human Glioblastoma

Elena Binda, Alberto Visioli, Nadia Trivieri, Angelo Vescovi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Grade IV gliomas, also known as glioblastoma multiforme (GBM), are incurable, lethal brain tumors, whose average life expectancy is around 15 months. There is a desperate need for a better understanding of the basic biology of these tumors, in order to devise novel, more specific and effective therapeutics. The handling of GBM represents a daunting challenge to clinicians, also considering the few therapeutic options available, none of which can significantly alter the inevitable lethal outcome of these tumors. Hence, the development of effective therapies would greatly benefit from the availability of in vivo GBM models that can reliably mimic the characteristics of malignant cells and the features of the human disease. Candidate new drugs have to be tested in these in vivo models by adopting settings concerning direct intra-brain delivery in order to define their overall therapeutic efficacy under clinical-like conditions. Here, we describe local intracranial delivery of drugs by osmotic mini-pumps.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press
Pages197-205
Number of pages9
Volume1869
DOIs
StatePublished - Jan 1 2019

Publication series

NameMethods in Molecular Biology
Volume1869
ISSN (Print)1064-3745

Keywords

  • Animal models
  • Drug delivery
  • Glioblastoma multiforme
  • Glioblastoma stem cells
  • Osmotic mini-pumps

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Fingerprint Dive into the research topics of 'Drug Delivery in an Orthotopic Tumor Stem Cell-Based Model of Human Glioblastoma'. Together they form a unique fingerprint.

Cite this